| 人参多糖对再灌注损伤兔肝脏能量代谢的改善作用及其机制 |
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| 引用本文： | 陈亮,唐兰兰,颜王鑫,张艳华,王淑君,黎关龙,王园园,王万铁. 人参多糖对再灌注损伤兔肝脏能量代谢的改善作用及其机制[J]. 中华中医药学刊, 2011, 0(5): 1111-1114 |
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| 作者姓名： | 陈亮 唐兰兰 颜王鑫 张艳华 王淑君 黎关龙 王园园 王万铁 |
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| 作者单位： | 温州市第三人民医院外科;温州医学院病理生理学教研室; |
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| 基金项目： | 温州市科技局资助项目(Y20060195) |
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| 摘 要： | 目的:探讨人参多糖对再灌注损伤兔肝脏能量代谢的改善作用及其机制。方法:30只家免,随机均分为对照组(C组),缺血/再灌注组(IR组)和人参多糖组(GP组)。分别观察血浆谷丙转氨酶(ALT)浓度和肝组织内三磷酸腺苷(ATP)、二磷酸腺苷(ADP)、一磷酸腺苷(AMP)、总腺苷酸量(TAN)、肝脏的细胞能荷(EC)、超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)、内皮素(ET)、NO/ET、血栓素B2(TXB2)、前列腺素F1α(PGF1α)、TXB2/PGF1α及肝细胞形态学的变化。结果:与C组比较,IR组血浆ALT、肝组织ADP、AMP、MDA、ET显著升高(P<0.01),TXB2、TXB2/PGF1α亦明显增高(P<0.05),肝组织ATP、EC、SOD、NO/ET明显下降(P<0.01),NO、PGF1α亦明显降低(P<0.05),TAN无显著性差异(P>0.05),肝细胞形态学明显异常;GP组较之IR组,血浆ALT、肝组织AMP、MDA、ET明显降低(P<0.01),肝组织ADP、TXB2/PGF1α亦显著减少(P<0.05),TXB2略低于IR组(P>0.05),肝组织ATP、EC、SOD、NO/ET显著升高(P<0.01),肝组织NO、PGF1α亦明显增高(P<0.05),TAN差异无显著性(P>0.05),肝细胞形态学异常明显减轻。结论:人参多糖可通过抗氧化及调节NO/ET及PGI2/TXA2比例失衡而改善肝组织能量代谢,从而有效防治肝脏再灌注损伤。
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| 关 键 词： | 人参多糖 再灌注损伤 能量代谢 肝脏 |
The Improvement of Ginseng Polysauharides Against Hepatic Reperfusion Injury on Energy Metabolism in Rabbits and Its Mechanism |
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| CHEN Liang,TANG Lan-lan,YAN Wang-xin,ZHANG Yan-hua,WANG Shu-jun,LI Guan-long,WANG Yuan-yuan,WANG Wan-tie. The Improvement of Ginseng Polysauharides Against Hepatic Reperfusion Injury on Energy Metabolism in Rabbits and Its Mechanism[J]. Chinese Archives of Traditional Chinese Medicine, 2011, 0(5): 1111-1114 |
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| Authors: | CHEN Liang TANG Lan-lan YAN Wang-xin ZHANG Yan-hua WANG Shu-jun LI Guan-long WANG Yuan-yuan WANG Wan-tie |
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| Affiliation: | CHEN Liang1,TANG Lan-lan2,YAN Wang-xin1,ZHANG Yan-hua2,WANG Shu-jun2,LI Guan-long2,WANG Yuan-yuan2,WANG Wan-tie2(1.Surgical department,The 3rd People's Hospital of Wenzhou,Wenzhou 325000,Zhejiang,China,2.Department of Pathophysiology,Wenzhou medical college,Wenzhou 325035,China) |
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| Abstract: | Objective: To observe the improvement of Ginseng Polysauharides against hepatic reperfusion injury on energy metabolism in rabbits and study its mechanism.Methods: 30 rabbits were randomly divided into 3 groups: control group(group C),ischemia/reperfusion injury group(group IR) and Ginseng Polysauharides group(group GP).We investigated alanine aminotransferase(ALT)in plasma,adenosine triphosphate(ATP),adenosine diphosphate(ADP),adenosine monphosphate(AMP),total adenylic acid number(TAN),energy charge(EC),su... |
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| Keywords: | Ginseng Polysauharides reperfusion injury energy metabolism liver |
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