| 牡丹皮饮片水提取浸膏对大鼠高脂性脂肪肝的干预作用 |
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| 引用本文： | 李向阳,龚其海,吴芹,张环英,李志毅.牡丹皮饮片水提取浸膏对大鼠高脂性脂肪肝的干预作用[J].中华中医药学刊,2011(4):896-898. |
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| 作者姓名： | 李向阳 龚其海 吴芹 张环英 李志毅 |
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| 作者单位： | 商丘医学高等专科学校药理学教研室;遵义医学院药理学教研室贵州省基础药理学重点实验室; |
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| 摘 要： | 目的:观察牡丹皮饮片水提取浸膏(CMPAE)对大鼠高脂性脂肪肝的药效学影响。方法:建立大鼠高脂性脂肪肝模型,同时采用灌胃给药,观察CMPAE对其血清脂质、肝功能、肝脏脂质以及氧化、抗氧化损伤指标的变化,并对肝脏组织进行病理学检查。结果:含生药量0.25g.mL-1、0.5g.mL-1和1g.mL-1的CMPAE可明显降低高脂性脂肪肝大鼠血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、丙氨酸氨基转移酶(ALT)和天冬氨酸氨基转移酶(AST)水平;同时观察到高脂性脂肪肝大鼠肝脏组织中TC、TG水平和丙二醛(MDA)含量明显下降,而超氧化物歧化酶(SOD)活性显著增高;肝脏组织病理学改变也在一定程度上得到了减轻。结论:CMPAE可明显抑制大鼠高脂性脂肪肝的形成,其作用机制可能与调节脂质代谢,抗氧化损伤有关。
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| 关 键 词： | 牡丹皮 高脂性脂肪肝 大鼠 |
Intervention effects of Cortex Moutan pieces aqueous extract on hyperlipidemic fatty liver in rats |
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| LI Xiang-yang,GONG Qi-hai,WU Qin,ZHANG Huan-ying,LI Zhi-yi,SHI Jing-shan.Intervention effects of Cortex Moutan pieces aqueous extract on hyperlipidemic fatty liver in rats[J].Chinese Archives of Traditional Chinese Medicine,2011(4):896-898. |
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| Authors: | LI Xiang-yang GONG Qi-hai WU Qin ZHANG Huan-ying LI Zhi-yi SHI Jing-shan |
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| Institution: | LI Xiang-yang1,2,GONG Qi-hai2,WU Qin2,ZHANG Huan-ying1,LI Zhi-yi1,SHI Jing-shan2(1.Department of Pharmacology,Shangqiu Medical School,Shangqiu 476005,Henan,China,2.Department of Pharmacology,Zunyi Medical School,The key Laboratory of Basic Pharmacology of Guizhou Province,Zunyi 563003,Guizhou,China) |
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| Abstract: | Objective: To investigate the pharmacodynamic effects of CMPAE on hyperlipidemic fatty liver in rats.Methods: Rat model of hyperlipidemic fatty liver was established,while the experimental rats were gavaged CMPAE.The changes of serum lipids,liver function,liver lipid and oxidation,anti-oxidative stress indicators were observed,and liver tissue was given pathological examination.Results: The levels of serum total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),alanine aminotransfe... |
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| Keywords: | Cortex Moutan hyperlipidemic fatty liver rat |
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