| 消瘀泄浊饮对肾间质纤维化大鼠的肾脏保护作用研究 |
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| 引用本文： | 鲁科达,张冰冰,谢志军,马红珍,何灵芝,李学铭. 消瘀泄浊饮对肾间质纤维化大鼠的肾脏保护作用研究[J]. 中华中医药学刊, 2011, 0(7): 1537-1540 |
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| 作者姓名： | 鲁科达 张冰冰 谢志军 马红珍 何灵芝 李学铭 |
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| 作者单位： | 浙江中医药大学附属第一医院;浙江中医药大学; |
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| 基金项目： | 国家“十一五”科技支撑计划资助项目(2007BAI10B01-034); 浙江省中医药管理局资助项目(2009YB004) |
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| 摘 要： | 目的:探讨消瘀泄浊饮对UUO模型大鼠的保护作用及作用机制。方法:实验采用UUO大鼠模型,将32只SD大鼠随机分为假手术组(S组)、模型组(M组)、洛汀新治疗组(B组)、消瘀泄浊饮组(X组)。分组用药并监测体重,给药14天后处死大鼠。测定大鼠左肾指数,血清肌酐、尿素氮、白蛋白水平;肾组织HE染色观察病理改变;用免疫组织化学方法检测肾组织α-SMA的表达。结果:消瘀泄浊饮能够明显降低实验大鼠血清肌酐、尿素氮水平,升高白蛋白水平,能降低肾组织中α-SMA蛋白表达,与模型组比较有显著性差异,形态学观察也显示其肾脏损害轻于模型组。结论:消瘀泄浊饮能有效地延缓肾间质纤维化的进程,可通过抑制α-SMA的表达,减少肌成纤维细胞的活化和形成,从而起到抗肾纤维化的作用。
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| 关 键 词： | 消瘀泄浊饮 肾间质纤维化 α-平滑肌肌动蛋白 |
The Protective Effect of Xiaoyu Xiezhuo Yin on Kidney of Renal Interstitial Fibrosis Rats |
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| LU Ke-da,ZHANG Bing-bing,XIE Zhi-jun,MA Hong-zhen,HE Ling-zhi,LI Xue-ming. The Protective Effect of Xiaoyu Xiezhuo Yin on Kidney of Renal Interstitial Fibrosis Rats[J]. Chinese Archives of Traditional Chinese Medicine, 2011, 0(7): 1537-1540 |
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| Authors: | LU Ke-da ZHANG Bing-bing XIE Zhi-jun MA Hong-zhen HE Ling-zhi LI Xue-ming |
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| Affiliation: | LU Ke-da1,ZHANG Bing-bing2,XIE Zhi-jun2,MA Hong-zhen1,HE Ling-zhi1,LI Xue-ming(1.The First Hospital Affiliated to Zhejiang Chinese Medical University,Hangzhou 310006,Zhejiang,China,2.Zhejiang Chinese Medical University,Hangzhou 310053,China) |
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| Abstract: | Objective:To investigate the protective effect and mechanism of Xiaoyu Xiezhuo Yin on UUO rats.Methods:In the experiment,unilateral ureteric obstruction(UUO) model is adopted,32 SD rats were randomly divided into 4 groups:sham-operated group(S group),model group(M group),benazepril treated group(B group),Xiaoyu Xiezhuo Yin treated group(X group).After being intragastric administrated respectively and monitored the weight for 2 weeks,all rats were executed.Left-kidney index,levels of serum creatinine,urea ni... |
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| Keywords: | Xiaoyu Xiezhuo Yin renal interstitial fibrosis alpha-smooth muscle actin |
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