银川市人群麻疹抗体水平检测分析及发病原因探讨

目的了解银川市健康人群麻疹抗体水平,结合麻疹发病情况,分析发病原因,为进一步制订麻疹防制策略提供科学依据。方法采用酶联免疫吸附试验(ELISA)对银川市0~29岁不同年龄组健康人群进行麻疹IgG抗体水平血清学检测,并对结果进行几何平均滴度(GMT)、F检验及x2检验分析。结果本次共检测1312份血清标本,阳性率为73.40%,抗体几何平均滴度(GMT)为1:420.58,保护率为51.75%。0~8月龄及25~29岁组抗体阳性率、保护率及GMT均较低,2~15岁组则较高;四类人群中城市人群保护率最高为72.88%,农村及流动人群较低,分别为65.82%和66.81%。结论今后应采取必要的措施加强我市0~8月龄和25~29岁年龄段人群麻疹疫苗的接种工作;定期对四类人群的接种效果进行评价,并加强流动及农村人口的强化免疫及麻疹疾病的监测,是控制麻疹流行的主要手段。

Analysis and Factors Influencing of Measles Antibody Levels among Population in Yinchuan City

Objective In order to understand the antibody level of measles in healthy populations in Yinchuan,we considered with the epidemic situation of measles and analyzed the etiological agents of measles to provide a scientific basis for the institution of preventive and controllable measures.Methods Populations in 0-29 aged in Yinchuan were selected and divided into different age groups,the cases were detected by ELISA for IgG antibodies.We analyzed the data with GMT,F-test and x2-test.Results Among the 1312 serum samples,the positive rate of measles antibody was 73.40 %,Geometric mean titers(GMT) was 1 : 420.58 and the antibody protection rate was 51.75%.The positive rate,protection rate and the GMT in aged 0-8 months infants and 25-29years were the significantly lowest,while in aged 2-15 years highest.The antibody protection rate in city dwellers was 72.88%,which was the highest in the four populations.The antibody protection rate in rural population and floating population were both lower and it were 65.82% and 66.81% respectively.Conclusion It was necessary to take some measures in order to enhance the routine vaccination of measles in aged 1-8 months and 25-29 years in future,estimate the effect of measles vaccination fort four populations,promote booster vaccination of measles in floating population and people in the countryside and reinforce surveillance.It was the main measure for controlling measles.