| 牡荆素对麻醉犬血流动力学及心肌耗氧量的影响 |
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| 引用本文： | 邵旭,董六一,李晓亮,郭岩,江勤,方明.牡荆素对麻醉犬血流动力学及心肌耗氧量的影响[J].安徽医药,2010,14(9):1001-1004. |
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| 作者姓名： | 邵旭 董六一 李晓亮 郭岩 江勤 方明 |
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| 作者单位： | 合肥七星医药科技有限公司,安徽,合肥,230088;抗炎免疫药理学省部共建教育部重点实验室,国家中医药管理局中药药理三级实验室,安徽医科大学药理学教研室,安徽,合肥,230032 |
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| 基金项目： | 国家科技部中小企业创新基金 |
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| 摘 要： | 目的研究牡荆素对麻醉犬血流动力学及心肌耗氧量的影响。方法杂种犬30只,人工呼吸下开胸,给药后观察其心率（HR）、血压（MAP）、心输出量（CO）、冠脉血流量（CBF）、左室压（LVP）及血氧含量。计算冠脉阻力（CVR）和体循环总外周阻力（TPR）等血流动力学指标。采用多普勒超声血流仪测定麻醉犬冠脉流量和心输出量,用血气分析仪测定血氧含量。结果牡荆素可减慢心率和左心室内压,并显著增加麻醉犬冠脉血流量和心输出量,降低总外周血管阻力和冠脉阻力,提高心搏出量、心搏指数及心脏指数。结论牡荆素可显著改善麻醉犬血流动力学参数。
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| 关 键 词： | 牡荆素 血流动力学 心肌耗氧量 犬 |
Effects of vitexin on hemodynamics and myocardial oxygen consumption in anesthetized dogs |
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| SHAO Xu,DONG Liu-yi,LI Xiao-liang,GUO Yan,JIANG Qin,FANG Ming.Effects of vitexin on hemodynamics and myocardial oxygen consumption in anesthetized dogs[J].Anhui Medical and Pharmaceutical Journal,2010,14(9):1001-1004. |
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| Authors: | SHAO Xu DONG Liu-yi LI Xiao-liang GUO Yan JIANG Qin FANG Ming |
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| Institution: | SHAO Xu1,DONG Liu-yi2,LI Xiao-liang1,GUO Yan2,JIANG Qin2,FANG Ming2(1.Hefei Qixing Medicine and Technology Co.Ltd,Hefei 230088,China;2.Key Laboratory of Antiinflammatory andImmunopharmacology,Ministry of Education,Key Laboratory of Chinese Medicine Research and Development,State Administration of Traditional Chinese Medicine,Department of Pharmacology,Anhui Medical University,Hefei 230032,China) |
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| Abstract: | Aim To investigate the effects of vitexin on hemodynamics and myocardial oxygen comsumption in anesthetized dogs.Methods In 30 dogs with artificial ventilation,the changes in parameters at different time were observed,such as heart rate(HR),mean arterial pressure(MAP),coronary blood flow(CBF),cardiac output(CO),left ventricular pressure(LVP)and blood oxygen content.The hemodynamic parameters,coronary vascular resistance(CVR),total peripheral resistance(TPR),stroke volume(SV),stroke index(SI),cardiac index(CI),left ventricle stroke work index(LVWI)and myocardium oxygen consumption index(MOCI)were calculated.Coronary artery blood flow and cardiac output were measured by Doppler flow meter.Blood oxygen content was determined by oximeter.Results Vitexin could significantly decline the HR and LVP,but could not change MAP.Vitexin could significantly increase coronary artery blood flow and cardiac output,reduce cerebral vascular resistance,total peripheral resistance and coronary vascular resistance,increase cardiac index,stroke index,stroke volume and decline myocardium oxygen consumption index.Conclusion Vitexin can improve the parameters of hemodynamics in anesthetized dogs. |
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| Keywords: | vitexin hemodynamics myocardial oxygen consumption dog |
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