7种动物与人的皮肤在药物渗透性中的比较

目的:为选择动物皮肤模型研究提供科学依据.方法:以苯甲酸、水杨酸、甲硝唑为模型药物,对小鼠、大鼠、兔、小猪、蛇、泥鳅、青蛙的皮肤进行Franz扩散池法的药物渗透实验,并与正常人体皮肤进行渗透性比较研究.结果:7种动物皮肤中对药物渗透性最大的为青蛙和泥鳅皮肤,渗透性较小的为猪、兔、蛇的皮肤,大部分动物皮肤渗透性比人体皮肤渗透性大.结论:小猪皮肤与人体皮肤对药物渗透性最为相似,选择小猪皮肤作为透皮吸收研究模型,是较理想的实验动物模型.

Comparative study of seven kinds of animal skins with human skin in skin permeability of druge

Objective :To undertake skin permeability of drugs using seven kinds of animals and human skin, and to provide scientific basis for choice of animal skin moder. Using benzoic acid acetylsalicylic acid metronidazole as model drugs and seven kinds of animal skins (mouse, rat, rabbit, pig, snake, loach and frog) for experimental material, the in-vitro skin permeability of drugs was undertaken in Frans diffusion cells. In the same conditions,the animal skins were compared with human skin in the rate and amount of the drug permeability through skin. Results: The skin permeabiltiy of frog and loach was more rapid and that of pig, rabbit and snake was slower. The drug permeability through the human skin was lower than the experimental animal skins. Conclusions: Pig skin has closer permeability properties with human skin than other animal skins. It can be regarded as a good animal mode for study of percutaneous permeability.