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Discovery of 4-(phenyl)thio-1H-pyrazole derivatives as agonists of GPR109A,a high affinity niacin receptor
Authors:Kim  Hyeon Young  Jadhav   Vithal B.  Jeong  Dae Young  Park   Woo Kyu  Song   Jong-Hwan  Lee   Sunkyung  Cho   Heeyeong
Affiliation:1.Research Center for Medicinal Chemistry, Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong, Daejeon, 305-343, Republic of Korea
;2.Research Center for Drug Discovery Technology, Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong, Daejeon, 305-343, Republic of Korea
;3.Korea University of Science and Technology, 141 Gajeong-ro, Yuseong, Daejeon, 305-343, Republic of Korea
;
Abstract:Archives of Pharmacal Research - Even though nicotinic acid (niacin) appears to have beneficial effects on human lipid profiles, niacin-induced cutaneous vasodilatation called flushing limits its...
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