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Kinetic and molecular docking studies of loganin and 7-O-galloyl-d-sedoheptulose from Corni Fructus as therapeutic agents for diabetic complications through inhibition of aldose reductase |
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| Authors: | Lee Chan Mee Jung Hyun Ah Oh Sang Ho Park Chan Hum Tanaka Takashi Yokozawa Takako Choi Jae Sue |
| Affiliation: | 1.Department of Food and Life Science, Pukyong National University, Busan, 608-737, Republic of Korea ;2.Department of Food Science and Human Nutrition, Chonbuk National University, Jeonju, 561-756, Republic of Korea ;3.Korean BioInformation Center (KOBIC), Daejeon, 305-806, Republic of Korea ;4.College of Korean Medicine, Daegu Haany University, Daegu, 706-060, Republic of Korea ;5.Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, 852-8521, Japan ;6.Graduate School of Science and Engineering for Research, University of Toyama, Toyama, 930-8555, Japan ; |
| Abstract: | Archives of Pharmacal Research - Aldose reductase (AR) is a key enzyme in the polyol pathway that is strongly implicated in the pathogenesis of diabetic complications. AR inhibitors have been... |
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