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Antibody Responses to Norovirus Genogroup GI.1 and GII.4 Proteases in Volunteers Administered Norwalk Virus |
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| Authors: | Nadim J. Ajami Meagan A. Barry Berenice Carrillo Zana Muhaxhiri Frederick H. Neill B. V. Venkataram Prasad Antone R. Opekun Mark A. Gilger David Y. Graham Robert L. Atmar Mary K. Estes |
| Affiliation: | aDepartments of Molecular Virology and Microbiology;bTranslational Biology and Molecular Medicine;cBiochemistry and Molecular Biology;dPediatrics;eMedicine, Baylor College of Medicine, Houston, Texas, USA |
| Abstract: | An assay was developed to detect antibodies against two norovirus proteases among participants in a Norwalk virus (GI.1) challenge study. Prechallenge seroprevalence was lower against the protease from the homologous GI.1 virus than against protease from a heterologous GII.4 strain. Seroresponses were detected for 14 of 19 (74%) infected persons. |
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