| 全身性红斑狼疮与人类白细胞抗原位点A、B |
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| 引用本文： | 康熙雄,王文怡,刘立,孙荣武.全身性红斑狼疮与人类白细胞抗原位点A、B[J].吉林大学学报(医学版),1984(4). |
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| 作者姓名： | 康熙雄 王文怡 刘立 孙荣武 |
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| 作者单位： | 白求恩医科大学第三临床学院免疫研究室
(康熙雄，王文怡，刘立)，白求恩医科大学第三临床学院免疫研究室(孙荣武) |
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| 摘 要： | <正> 全身性红斑狼疮(SLE)是一种侵犯多系统,产生多种自身抗体的自身免疫性疾病。病因学尚不完全清楚。近年来随着医学,特别是免疫学的迅速发展及新技术的应用,对SLE病因的研究已有了较大的进展。认为它是遗传因素和慢性病毒感染及其它诱因相互作用下使机体免疫功能发生紊乱,抑制性T细胞功能减弱,B细胞功能增强,在补体作用下引起
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Systemic lupus erythematosus and HLA-A.B antigens |
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| Abstract: | Human leucocyte antigens(HLA)-A,B typing was carried out in 48 SLE patients, with 46 healthy subjects serving as the control group. The frequency of HLA antigens B40 was greater in SLE patients as compared with that of the controls (X2 = 15.41, P<0.01); the frequency of HLA antigens AH was also greater in SLE patients than that of the controls (X2=4.88, P<0.05) . The frequency of HLA-A11 and B40 was 40% in SLE patients, that of the controls being 10%. Three patients in one family in the 48 SLE patients were AH and B40 positive. |
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