Autophagy plays a protective role against apoptosis induced by toxicarioside N via the Akt/mTOR pathway in human gastric cancer SGC-7901 cells |
| |
Authors: | Huan-Ge Zhao Song-Lin Zhou Ying-Ying Lin Hua Wang Hao-Fu Dai Feng-Ying Huang |
| |
Institution: | 1.Key Laboratory of Tropical Diseases and Translational Medicine of the Ministry of Education,Hainan Medical College,Haikou,China;2.Hainan Provincial Key Laboratory of Tropical Medicine,Hainan Medical College,Haikou,China;3.Institutes of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou,China |
| |
Abstract: | Toxicarioside N (Tox N), a natural product extract from Antiaris toxicaria, has been reported to induce apoptosis in human gastric cancer cells. However, the mechanism and actual role of autophagy in Tox N-induced apoptosis of human gastric cancer cells remains poorly understood. In the current study, we demonstrated that Tox N could induce autophagy by inhibiting the Akt/mTOR signaling pathway in SGC-7901 cells. Moreover, we found that the inhibition of autophagy by 3-methyladenine, an autophagy inhibitor, enhanced Tox N-induced apoptotic cell death. However, the stimulation of autophagy by rapamycin, an autophagy activator, remarkably suppressed Tox N-induced apoptosis, suggesting that autophagy plays a protective role in Tox N-induced apoptosis. Thus, the results from this study suggested that Tox N combination with an autophagy inhibitor might be a promising strategy to enhance the anticancer activity of Tox N for the treatment of human gastric cancer. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|