局部注射人舌癌肿瘤浸润淋巴细胞在动物模型体内的动态分布

用＾３Ｈ－胸腺嘧啶核苷（＾３Ｈ－ＴｄＲ）标记体系培养４周的人舌癌肿瘤浸润淋巴细胞（ＴＩＬ）。在建立人舌癌裸鼠移植瘤模型 ，作＾３Ｈ－ＴＩＬ的瘤周注射，通过检测每克组织的放射活性间接掩映＾３Ｈ－ＴＩＬ在体内的动态分布。结果发现，人舌癌ＴＩＬ瘤周注射后分布到全身各器官组织中；在肿瘤组织的聚集量是正常组织的２．１￣３０倍，并且能聚集在远离注射部位的肿瘤组织。肿瘤组织离注射部位越近，其聚集量越多。提示，人

Dynamic Distribution in Vivo of TIL from Human Tongue Cancer After Local Injection in Animal Model

On the basis of established nude mice transplanted tumor model of human tongue squamous cell carcinoma, peritumor injection was performed with 3H-TdR labeled TIL from human tongue cancer after 4 weeks culture. The dynamic distribution of 3H-TIL in vivo was learned through detecting the radioactivity of the target tissues. The results demonstrated that 3H-TIL was found in the whole body. There were about 2.1-30 times more in tumor tissues than in normal tissues and 3H-TILs even collected in the tumor tissues distal to the injective sites. The nearer to the injective sites the tumor tissues, the more 3H-TIL collected. It showed that local injection of TIL could be expected to exert a better antitumor effect.