肝脏局灶性结节性增生48例临床分析

目的 探讨肝脏局灶性结节性增生(FNH)准确诊断和合理治疗的方法。方法 对48例FNH患者的临床资料进行总结,分析其临床病理特征。全部患者均行手术切除并经病理证实。结果 大多数FNH患者无明显症状,血清学检查正常。25例患者的CT和MRI检查均有一定的特征性表现。29例FNH病灶切面具有典型的星状疤痕。全组患者手术并发症发生率2．1％,无手术死亡。随访4年未见肿瘤复发。结论 FNH发病与服用避孕药关系不大;CT和MRI对FNH具有较高的诊断价值;手术切除是FNH首选的治疗方法,但对诊断明确而瘤体较小、无明显症状的FNH患者,可密切随访及定期观察。

Focal nodular hyperplasia of the liver: a clinical study of 48 patients

Objective To study the diagnosis and proper treatment of focal nodular hyperplasia (FNH) of the liver. Methods Forty-eight consecutive patients with FNH treated from 1998 to 2002 were analyzed. Clinical, pathologic, and preoperative imaging findings of FNH all proved surgically and pathologically were retrospectively reviewed. Results Most of the patients were asymptomatic and serum test was normal. Helical multiphasic liver CT and MR imaging demonstrated characteristic features in 25 patients. Histologically, characteristic scar-like tissues were found in 29 cases. The overall complication rate was 2.1% and there was no death. No recurrence was observed after follow-up of 4 years after operation. Conclusion There is little evidence for an increased risk for FNH in people using modern oral contraceptives, while characteristic imaging features exist in helical multiphasic liver CT and MR imaging. Operation is the optimal treatment for FNH, but for proved FNH less than 5 cm and asymptomatic patients, close periodic followed up should be done.