| 白细胞介素8在兔缺血再灌注脊髓损伤中的作用 |
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| 引用本文： | 张洪涛 杨惠林 刘继明 曲静 张学光 唐天驷 杨同其. 白细胞介素8在兔缺血再灌注脊髓损伤中的作用[J]. 苏州大学学报(自然科学版), 2005, 25(6): 975-977 |
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| 作者姓名： | 张洪涛 杨惠林 刘继明 曲静 张学光 唐天驷 杨同其 |
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| 作者单位： | [1]苏州大学附属第一医院骨科,江苏苏州215006 [2]苏州大学生命科学学院,江苏苏州215007 |
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| 摘 要： | 目的 探讨兔缺血再灌注脊髓组织中白细胞介素8（IL-8）趋化诱导中性粒细胞（PMNL）的作用。方法 分非抗IL-8抗体组和抗IL-8抗体组，采用免疫组化和组织病理学方法，观察抗IL-8抗体使用前后再灌注脊髓组织中IL-8的表达及PMNL浸润情况。结果 再灌注12h，脊髓组织中IL-8呈强阳性表达并可见大量PMNL浸润，使用抗IL-8抗体后，组织中IL-8被清除，PMNL浸润明显减少。结论 缺血再灌注脊髓损伤中，IL-8可强烈地趋化诱导PMNI。在组织中的浸润，其在炎症反应引起的继发性损伤中发挥重要作用。
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| 关 键 词： | 白细胞介素8 中性粒细胞 脊髓损伤 缺血再灌注 兔 |
| 文章编号： | 1673-0399(2005)06-0975-03 |
| 收稿时间： | 2005-03-11 |
| 修稿时间： | 2005-03-11 |
The Role of Interleukin-8 during the Spinal Cord Ischemia/Reperfusion in Rabbits |
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| ZHANG Hong-tao, YANG Hui-ling, TANG Tian-si, et al. The Role of Interleukin-8 during the Spinal Cord Ischemia/Reperfusion in Rabbits[J]. Suzhou University Journal of Medical Science, 2005, 25(6): 975-977 |
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| Authors: | ZHANG Hong-tao YANG Hui-ling TANG Tian-si et al |
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| Affiliation: | 1. Dept of Orthopaedics, the First Hospital Affiliated to Suzhou University, Jiangsu Suzhou 215006 ; 2. School of Life Science, Suzhou University, Jiangsu Suzhou 215007, China |
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| Abstract: | Objective To explore the effect of interleukin-8(IL-8) inducing polymorphonuclear leukocyte(PMNL) in spinal cord during the ischemia/reperfusion(I/R) in rabbits.Methods Rabbits were randomly divided into the non-anti-IL-8 antibody group and anti-IL-8 antibody group;the expression of IL-8 and the number of PMNL in spinal cord I/R(SCI/R) were evaluated by means of immunohistochemical and histopathological methods.Results The positive expression of IL-8 and the number of PMNL progressively increased following reperfusion and histopathologic exacerbation.PMNL infiltration and positive expression of IL-8 in tissue were obviously diminised with anti-IL-8 antibody.Conclusion During the SCI/R,IL-8 may intensivly induce PMNL into the parenchyma;IL-8 acts an important role in the spinal cord I/R injury. |
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| Keywords: | interleukin-8 polymorphonuclear leukocyte spinal cord injury ischemia/reperfusion |
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