| 功能磁共振观察额叶癫痫患者静息态局域一致性 |
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| 引用本文： | 林玉姣,张志强,许强,陈光辉,杨昉,卢光明. 功能磁共振观察额叶癫痫患者静息态局域一致性[J]. 中国医学影像技术, 2013, 29(10): 1585-1588 |
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| 作者姓名： | 林玉姣 张志强 许强 陈光辉 杨昉 卢光明 |
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| 作者单位： | 南京大学医学院临床学院南京军区南京总医院医学影像科, 江苏 南京 210002;南京大学医学院临床学院南京军区南京总医院医学影像科, 江苏 南京 210002;南京大学医学院临床学院南京军区南京总医院医学影像科, 江苏 南京 210002;南京大学医学院临床学院南京军区南京总医院神经内科, 江苏 南京 210002;南京大学医学院临床学院南京军区南京总医院神经内科, 江苏 南京 210002;南京大学医学院临床学院南京军区南京总医院医学影像科, 江苏 南京 210002 |
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| 基金项目： | 国家自然科学基金面上项目(81271553);国家自然科学基金中外合作重大项目(81020168022) |
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| 摘 要： | 目的 探讨静息状态下额叶癫痫(FLE)患者局域一致性(ReHo)的变化特点.方法 对46例常规结构MRI阴性FLE患者及性别年龄无差异的正常对照组行静息态fMRI,比较 ReHo改变脑区,观察ReHo改变脑区与FLE病程长短的相关性.结果 相比正常对照组,FLE患者ReHo值升高的脑区包括前、中扣带回,双侧岛叶、丘脑及右侧基底核区,ReHo降低脑区包括左侧额上回,左侧颞中、下回及小脑.相关性分析结果显示,FLE患者前、中扣带回,额上回ReHo值与病程长短呈正相关,双侧辅助运动区、右侧枕叶ReHo值与病程呈负相关.结论 FLE患者静息态下脑功能异常,扣带回、岛叶、丘脑及基底核区等区域存在ReHo改变.
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| 关 键 词： | 额叶癫痫 局域一致性 磁共振成像 |
| 收稿时间： | 2013-05-10 |
| 修稿时间： | 2013-07-15 |
Observation on regional homogeneity in frontal lobe epilepsy patients based on resting state functional MRI |
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| LIN Yu-jiao,ZHANG Zhi-qiang,XU Qiang,CHEN Guang-hui,YANG Fang and LU Guang-ming. Observation on regional homogeneity in frontal lobe epilepsy patients based on resting state functional MRI[J]. Chinese Journal of Medical Imaging Technology, 2013, 29(10): 1585-1588 |
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| Authors: | LIN Yu-jiao ZHANG Zhi-qiang XU Qiang CHEN Guang-hui YANG Fang LU Guang-ming |
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| Affiliation: | Department of Medical Imaging, Clinical College of Medical School of Nanjing University, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China;Department of Medical Imaging, Clinical College of Medical School of Nanjing University, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China;Department of Medical Imaging, Clinical College of Medical School of Nanjing University, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China;Department of Neurology, Clinical College of Medical School of Nanjing University, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China;Department of Neurology, Clinical College of Medical School of Nanjing University, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China;Department of Medical Imaging, Clinical College of Medical School of Nanjing University, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China |
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| Abstract: | Objective To assess the changes of regional homogeneity (ReHo) in frontal lobe epilepsy patients. Methods Resting state fMRI was performed on 46 structural MRI-negative frontal lobe epilepsy (FLE) patients and 46 normal controls. The difference of ReHo between FLE patients and controls were analyzed. Then the correlation between ReHo and epilepsy duration of FLE was investigated. Results Compared with normal controls, FLE patients presented increased ReHo in anterior cingulate, middle cingulate, bilateral insula, thalamus and basal ganglia, while decreased ReHo in left superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus and cerebellum. Correlation analysis showed that ReHo in anterior cingulate, middle cingulate and superior temporal gyrus positively correlated with epilepsy duration, while ReHo in bilateral supplementary motor area negatively correlated with epilepsy duration and right occipital. Conclusion Significant brain dysfunction can be seen in resting state of FLE patients, and ReHo values of cingulate gyrus, insula, thalamus and basal ganglia have been altered. |
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| Keywords: | Frontal lobe epilepsy Regional homogeneity Magnetic resonance imaging |
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