熊去氧胆酸和多潘立酮片治疗胆汁反流性胃炎的疗效观察

目的:探讨熊去氧胆酸和多潘立酮片对胆汁反流性胃炎的疗效。方法:45例经胃镜检查证实的胆汁反流性胃炎患者随机分为三组,A组服用熊去氧胆酸(250mg,每日1次);B组服用多潘立酮片(10mg,每日3次);C组同时服用熊去氧胆酸和多潘立酮片。观察治疗后腹痛、腹胀、呕吐胆汁等症状变化情况,4周后复查胃镜。结果:治疗后三组患者症状均明显减轻(P<0.01),有效率分别为86.7%、93.3%和100%。症状平均消失时间为8.6d、7.9d和5.4d,C组与前两组比较有显著性差异(P<0.05)。胃内胆汁反流消失率分别为81.8%、84.6%和92.9%。结论:熊去氧胆酸联合多潘立酮片可减少胃内胆汁反流,能有效缓解胆汁反流性胃炎的症状。

Effect of ursodeoxycholic and domperidone on bile-reflux gastritis

Objective:To evaluate the effect of ursodeoxycholic(UDCA) and domperidone in bile-reflux gastritis.Methods:45 patients with bile-reflux gastritis proven by gastroscopy were divided into 3 groups equally at random,which were treated with UDCA 250 mg one day;domperidone 10 mg three times a day and both drugs respectively.The severity of the symptoms including abdominal pain,abdominal distention,nausea and bile vomitus were investigated before and four weeks after treatment.Gastroscopy was also reexamined.Results:The severity of the symptoms in the three groups decreased greatly after treatment(P<0.01).Average disappearance in a symptom were 8.6 days,7.9 days and 5.4 days.The difference in three groups was statistically significant (P<0.05).The disappearance rate of intraastric bile-reflux in three groups were 81.8%,84.6%和92.9%.Conclusion:UDCA combined domperidone can decrease the intragastric bile reflux,and are effective in bile reflux gastriris.