血液灌流联合环磷酰胺和甲基强的松龙治疗百草枯中毒的疗效与安全性

目的观察血液灌注联合环磷酰胺和甲基强的松龙治疗百草枯中毒患者的近期疗效。方法回顾性分析运城市中心医院2003—01～2008-01收治的百草枯中毒患者72例，其中血液灌流联合环磷酰胺和甲基强的松龙治疗患者（联合治疗组）38例，血液灌流不联合环磷酰胺和甲基强的松龙治疗患者（常规治疗组）34例。比较2组间患者的临床特征，30d死亡率、肺纤维化发生率、多脏器功能衰竭发生率及肺纤维化发生时间。结果两组患者临床特征差异无统计学意义（P〉0．05）；联合治疗组较常规治疗组死亡率显著降低（10．52％船38．23％，P=0．013），肺纤维化发生率（2．60％惦18．91％，P=0．041）和多器官衰竭发生率也显著下降（0vs14．70％，P=0．047），肺纤维化发生时间的差异无统计学意义（P=0．483），同时总的严重并发症发生率差异也无统计学意义（2．60％∞0，P=0．955）。结论血液灌注联合环磷酰胺和甲基强的松龙治疗百草枯中毒早期疗效是确切的。

Effectiveness and safety of hemoperfusion therapy combined with cyclophosphamide and methylprednisolone for patients with paraquat poisoning

Objective To observe the effectiveness and safety of hemoperfusion therapy combined with cyclophosphamide and methylprednisolone for paraquat poisoning. Methods From January 2003 to January 2008,a total of 72 paraquat poisoning patients in Yuncheng Central Hospital were treated with hemoperfusion therapy combined with cyclophosphamide and methylprednisolone(therapeutic alliance group,n=38)or without(conventional therapy group,n=34).Clinical characteristics,30 d fatality rate,the incidence of pulmonary fibro...