IgG4‐related disease manifesting the gastric wall thickening |
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| Authors: | Hiroo Kawano Aya Ishii Tokuhiro Kimura Tsuyoshi Takahashi Hideharu Hironaka Michitaka Kawano Michiya Yamaguchi Keiji Oishi Makoto Kubo Shoko Matsui Kenji Notohara Eiji Ikeda |
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| Affiliation: | 1. Department of Laboratory Science, Faculty of Health Science, Yamaguchi University Graduate School of Medicine, Ube, Japan;2. Department of Pathology, Yamaguchi University Graduate School of Medicine, Ube, Japan;3. Department of Surgery, Saiseikai Yamaguchi Hospital, Yamaguchi, Japan;4. Department of Internal Medicine, Saiseikai Yamaguchi Hospital, Yamaguchi, Japan;5. Department of Dermatology, Yamaguchi University Graduate School of Medicine, Ube, Japan;6. Department of Internal medicine, Ube Medical Center, Ube, Japan;7. Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan;8. Health Administration Center, Toyama University, Toyama, Japan;9. Department of Anatomic Pathology, Kurashiki Central Hospital, Kurashiki, Japan |
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| Abstract: | IgG4‐related disease (IgG4‐RD) is a recently designated disease entity and its full picture has not yet been elucidated. Here, we report an unusual case of a patient with gastric wall thickening secondary to IgG4‐RD. A 68‐year‐old male visited our hospital with itchy skin lesions and an episode of organizing pneumonia. On the suspicion of malignancy‐associated skin lesions, computed tomography (CT) was performed. The CT revealed prominent thickening of the gastric wall. Due to the possibility of malignancy, the patient underwent distal gastrectomy. Histopathological examination showed fibrosis of the submucosa and prominent thickening of the muscularis propria. Most of infiltrating cells were IgG4‐positive plasma cells. Post‐operative blood test revealed significantly high serum levels of total IgG and IgG4. Based on these histological features, the patient was given a definitive diagnosis of IgG4‐RD. Further accumulation of cases like the present case that develop IgG4‐RD with rare manifestations would lead to the elucidation of pathogenesis. |
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| Keywords: | gastric wall thickening IgG4 IgG4‐related disease |
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