| 钠碘转运体基因介导的肿瘤放射性核素治疗研究 |
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| 引用本文： | 张俊,刘增礼. 钠碘转运体基因介导的肿瘤放射性核素治疗研究[J]. 国际放射医学核医学杂志, 2008, 32(1): 8-11 |
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| 作者姓名： | 张俊 刘增礼 |
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| 作者单位： | 1. 225300 江苏, 江苏省泰州市人民医院核医学科;;2. 215004 苏州, 苏州大学附属第二医院核医学科 |
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| 摘 要： | 钠碘转运体(NKS)是一种跨膜糖蛋白,介导碘的主动摄取,使得放射性碘用于治疗不摄碘的肿瘤成为可能。目前NIS基因已被成功转入多种肿瘤并表达出有功能的NIS蛋白,但治疗的效果并不令人满意。为此,研究者们应用不同的方法进行了改进,并收到较好的效果。
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| 关 键 词： | 基因疗法 碘放射性同位素 肿瘤 钠碘转运体 |
| 收稿时间： | 2007-07-05 |
Sodium iodide symporter gene-mediated radionuclide therapy of tumors |
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| ZHANG Jun,LIU Zeng-li. Sodium iodide symporter gene-mediated radionuclide therapy of tumors[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2008, 32(1): 8-11 |
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| Authors: | ZHANG Jun LIU Zeng-li |
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| Affiliation: | 1. Department of Nuclear Medicine, Taizhou People's Hospital, Taizhou 225300, China;;2. Department of Nuclear Medicine, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China |
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| Abstract: | The sodium iodide symporter(NIS)is a transmembrane glycoprotein responsible for uptake of iodide into cells.It has raised the possibility of using radio-iodine for treatment of those tumors that cannot accumulate iodide.The NIS gene has been transferred into a variety of tumors and induced NIS functional expression successfully.However,the effect of therapy is disappointing.Hence,many investigators apply several different approaches to their studies and obtain more effective results. |
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| Keywords: | Gene therapy Iodineradioisotopes Neoplasms Sodium iodide svmporter |
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