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Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism |
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| Authors: | Maria Bruzelius Rona J Strawbridge David-Alexandre Trégouët Kerri L Wiggins Karl Gertow Maria Sabater-Lleal John Öhrvik Annica Bergendal Angela Silveira Anders Sundström Helle Kieler Ann-Christine Syvänen Nicholas L Smith Pierre-Emmanuel Morange Jacob Odeberg Anders Hamsten |
| Institution: | 1. Coagulation Unit, Hematology Centre, Karolinska University Hospital Solna, Sweden;2. Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden;3. INSERM, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, F-75013, Paris, France;4. ICAN Institute for Cardiometabolism and Nutrition, F-75013, Paris, France;5. Department of Medicine, University of Washington, Seattle WA USA;6. Centre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden;g Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden;h Department of Epidemiology, University of Washington, Seattle WA USA;i Group Health Research Institute, Group Health Cooperative, Seattle WA USA;j Seattle Epidemiologic Research and Information Center, Veterans Affairs Office of Research and Development, Seattle WA 98101, USA;k Inserm UMR 1062, Marseille, Aix-Marseille Université, Marseille, France;l Science for Life Laboratory Stockholm, Department of Proteomics, School of Biotechnology, KTH, Solna, Sweden;m Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, F-75013, Paris, France |
| Abstract: | IntroductionWe investigated whether genetic variations robustly associated with coronary artery disease are also associated with risk of venous thromboembolism in a well-defined, female case–control study (n = 2753) from Sweden.Materials and Methods39 single nucleotide polymorphisms in 32 loci associated with coronary artery disease in genome-wide association studies were identified in a literature search and genotyped in the ThromboEmbolism Hormone Study (TEHS). Association with venous thromboembolism was assessed by logistic regression.ResultsOnly rs579459 in the ABO locus demonstrated a significant association with VTE. A tentative association between ANRIL and VTE in the discovery analysis failed to replicate in a meta-analysis of 4 independent cohorts (total n = 7181).ConclusionsIt appears that only the ABO locus is a shared risk factor for coronary artery disease and VTE. |
| Keywords: | BMI body mass index CAD Coronary artery disease DVT deep vein thrombosis PE pulmonary embolism SNP single nucleotide polymorphism VTE venous thromboembolism TEHS The ThromboEmbolism Hormone Study FARIVE The Facteurs de risque et de ré cidive de la maladie thromboembolique veineuse study HVH The Heart and Vascular Health Study MARTHA The Marseille Thrombosis Association study EOVT The Early Onset of Venous Thrombosis study |
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