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Microparticle bearing tissue factor: A link between promyelocytic cells and hypercoagulable state |
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| Authors: | Damien Gheldof François Mullier Nicolas Bailly Bérangère Devalet Jean-Michel Dogné Bernard Chatelain Christian Chatelain |
| Institution: | 1. Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU UCL Mont-Godinne-Dinant, Université Catholique de Louvain, Belgium;2. Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Belgium;3. Hematology, CHU UCL Mont-Godinne-Dinant, Université Catholique de Louvain, Belgium |
| Abstract: | Patients with hematological malignancies have a 28-fold increased risk of venous thromboembolism (VTE). Among patients with acute myelogenous leukemia (AML), the 2-year cumulative incidence of VTE is 5.2%. Several studies suggest that microvesicles (MVs) harboring TF may play a role in VTE and disseminated intravascular coagulation (DIC) in acute promyelocytic leukemia (APL). |
| Keywords: | Leukemia AMLM3 Thrombosis Tissue factor Microvesicles |
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