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Risk of coronary artery disease in patients with idiopathic inflammatory myopathies: A systematic review and meta-analysis of observational studies
Authors:Patompong Ungprasert  Promporn Suksaranjit  Ittikorn Spanuchart  Napat Leeaphorn  Nitipong Permpalung
Affiliation:1. Department of Medicine, Faculty of medicine Siriraj hospital, Mahidol University, Bangkok 10700, Thailand;2. Department of Cardiology, University of Utah School of Medicine, Salt Lake City, UT;3. Department of Internal Medicine, John A. Burns School of medicine, University of Hawaii, Honolulu, HI;4. Department of Internal Medicine, Bassett Medical Center, Columbia University College of Physicians and Surgeons, Cooperstown, NY
Abstract:

Objectives

To investigate the risk of coronary artery disease in patients with idiopathic inflammatory myopathies (IIM).

Methods

We conducted a systematic review and meta-analysis of observational studies that reported odds ratios, relative risks, hazard ratios, or standardized incidence ratios comparing the risk of coronary artery disease in patients with IIM versus non-IIM participants. We searched published studies indexed in MEDLINE, EMBASE, and the Cochrane database from inception to December 2013 using the terms “coronary artery disease” OR “coronary heart disease” OR “myocardial infarction” OR “atherosclerosis” combined with the terms “dermatomyositis” OR “polymyositis” OR “Idiopathic inflammatory myopathy.” Pooled risk ratio and 95% confidence interval were calculated using a random-effect, generic inverse variance method.

Result

Overall, four studies were identified and included for data analysis. The pooled risk ratio of CAD in patients with IIM was 2.24 (95% CI: 1.02–4.92). The statistical heterogeneity of this meta-analysis was high with an I2 of 97%.

Conclusion

Our study demonstrated a statistically significant increased risk of CAD among patients with IIM.
Keywords:Dermatomyositis   Polymyositis   Idiopathic inflammatory myopathies   Coronary artery disease   Atherosclerosis   Meta-analysis
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