Five-year follow-up of left ventricular diastolic function in systemic sclerosis patients: Determinants of mortality and disease progression |
| |
Authors: | Réka Faludi MD PhD Gyöngyvér Költő Barbara Bartos Georgina CsimaLászló Czirják MD DSc András Komócsi |
| |
Institution: | 1. Faculty of Medicine, Heart Institute, University of Pécs, Pécs, Hungary;2. Somogy County Kaposi Mór Teaching Hospital, Kaposvár, Hungary;3. Faculty of Medicine, 1st Department of Internal Medicine, University of Pécs, Pécs, Hungary;4. Faculty of Medicine, Department of Rheumatology and Immunology, University of Pécs, Pécs, Hungary |
| |
Abstract: | ObjectivesIn systemic sclerosis (SSc), left ventricular diastolic dysfunction reflects primary myocardial involvement of the disease. We aimed to assess the abnormalities of the diastolic function, analyze the characteristics of the disease progression, and investigate the prognostic value of diastolic dysfunction in SSc patients.Patients and methodsA total of 34 SSc patients (57 ± 12 years, 31 female) were involved in the study. The following traditional or tissue Doppler parameters of left ventricular diastolic function were obtained: E/A, lateral E?, E/E?, left ventricular mass index (LVM index), and maximal left atrial (LA) volume index. Measurements were repeated after 5.5 years.ResultsAt baseline, diastolic dysfunction was found in 62% of the SSc patients. Follow-up time was 5.4 ± 1.2 years. A total of 6 patients died of heart failure. In univariate Cox regression analysis, age (HR = 1.08, p < 0.05), LVM index (HR = 1.07, p < 0.01), lateral E? (HR = 1.57, p = 0.05), and LA volume index (HR = 1.11, p < 0.01) were predictors of survival. During the follow-up, significant increase in LA volume index (27.5 ± 9.7 vs. 35.4 ± 10.6 cm3/m2, p < 0.001) and E/E? was found (7.6 ± 2.5 vs. 8.7 ± 3.8, p < 0.05) while E? did not change (9.6 ± 2.6 vs. 9.2 ± 1.9 cm/s, NS). The increase in LA volume index showed positive correlation (r = 0.46, p < 0.05) while the decrease in E? values showed negative correlation (r = −0.54, p < 0.01) with the duration of the SSc.ConclusionIn SSc patients, left ventricular diastolic dysfunction is highly prevalent and is associated with increased risk of mortality. Our data suggest that in the advanced phase of the disease, the myocardial fibrotic processes burns out while the increase of the filling pressure progresses continuously. |
| |
Keywords: | Systemic sclerosis Diastolic dysfunction Myocardial fibrosis Disease progression Mortality Survival Follow-up Tissue Doppler imaging |
本文献已被 ScienceDirect 等数据库收录! |
|