| 一个新颖的人参皂苷元衍生物及其抗HL-60肿瘤细胞活性 |
| |
| 引用本文： | 李辉峰,郭洪祝,果德安.一个新颖的人参皂苷元衍生物及其抗HL-60肿瘤细胞活性[J].中草药,2010,41(1):6-8. |
| |
| 作者姓名： | 李辉峰 郭洪祝 果德安 |
| |
| 作者单位： | 1. 北京大学药学院生物技术室,北京,100083
2. 北京大学药学院生物技术室,北京,100083;北京市药品检验所,北京,100035 |
| |
| 基金项目： | 教育部博士点基金课题(20040001136) |
| |
| 摘 要： | 目的研究人参皂苷元衍生物及其抗HL-60肿瘤细胞活性。方法利用Smith降解处理人参总皂苷,采用硅胶柱色谱、制备型高效液相色谱技术分离、纯化人参皂苷元等产物。通过波谱数据分析产物结构。采用MTT法测试产物抗HL-60肿瘤细胞活性。结果分离鉴定了原人参二醇(PD)、原人参三醇(PT)和24,25-烯-3β,6α-二羟基-12,20-(1′-羟基)双氧乙基-达玛烷(1),化合物1为新化合物命名为1′-羟基双氧乙基原人参三醇。结论化合物1为新型人参皂苷元衍生物,其抑制HL-60细胞增殖的作用强于PD和PT。
|
| 关 键 词： | 1′-羟基双氧乙基原人参三醇 人参皂苷元衍生物 HL-60细胞 |
| 收稿时间： | 2009/6/12 0:00:00 |
A novel derivative of ginsenoside sapogenin and its activity against HL-60 cells |
| |
| LI Hui-feng,GUO Hong-zhu and GUO De-an.A novel derivative of ginsenoside sapogenin and its activity against HL-60 cells[J].Chinese Traditional and Herbal Drugs,2010,41(1):6-8. |
| |
| Authors: | LI Hui-feng GUO Hong-zhu and GUO De-an |
| |
| Institution: | LI Hui-feng1,GUO Hong-zhu1,2,GUO De-an1(1.Department of Biotechnology,School of Pharmaceutical Sciences,Peking University,Beijing 100083,China,2.Beijing Institute for Drug Control,Beijing 100035,China) |
| |
| Abstract: | Objective To investigate the derivatives of ginsenoside sapogenins and their activities against HL-60 cells.Methods The total ginsenoside extract was treated by Smith degradation.All products were isolated by silica gel chromatography and purified by preparative HPLC.On the basis of 1D and 2D NMR data,structures were elucidated.The activity against HL-60 cells was measured by MTT method.Results Three compounds were isolated and identified as 20(S)-protopanaxadiol(PD),20(S)-protopanaxatriol(PT),and 24,25-en-... |
| |
| Keywords: | 1'-hydroxy ethanedioxy protopanaxatriol ginsenoside sapogenin derivative HL-60 cells |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《中草药》浏览原始摘要信息 |
| 点击此处可从《中草药》下载免费的PDF全文 |
|
