Colonic tumorigenesis in rats with 1,2-dimethylhydrazine |
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| Authors: | Dr. P. F. Hagihara M.D. K. Yoneda M.D. C. R. Sachatello M.D. H. Hedgecock Ph.D. J. W. Flesher Ph.D. M. D. Ram M. D. Ph.D. W. O. Griffen M.D. Ph.D. D. M. Goldenberg Sc.D. M.D. |
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| Affiliation: | (1) Department of Surgery, Veterans Administration Medical Center and University of Kentucky College of Medicine, 40536 Lexington, Kentucky;(2) Department of Pathology, Veterans Administration Medical Center and University of Kentucky College of Medicine, 40536 Lexington, Kentucky;(3) Department of Pharmacology, Veterans Administration Medical Center and University of Kentucky College of Medicine, 40536 Lexington, Kentucky |
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| Abstract: | Subcutaneous injections of the carcinogen dimethylhydrazine in inbred Fischer 344 male rats induced squamous-cell carcinomas in the ear canal, adenocarcinomas in the small bowel and duodenum, and adenomas and adenocarcinomas in the large bowel. The incidences of the tumors induced in the large bowel and ear canal were dose-related. As for tumors of the large bowel, the average size of adenomas was less than that of adenocarcinomas with massive infiltration beyond the muscularis mucosa. The average size of early adenocarcinomas was greater than that of adenomas but less than that of adenocarcinomas with massive infiltration beyond the muscularis mucosa. Supported by Medical Research Service, Veterans Administration Medical Center, Lexington, Kentucky. |
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| Keywords: | Carcinogen(s), dimethylhydrazine Dimethylhydrazine Adenoma, experimental, rats Adenocarcinoma, experimental, rats Carcinoma, squamous-cell, rats Colon, carcinogenesis, rats |
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