| PI3K/Akt信号通路与肝纤维化 |
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| 引用本文： | 黄成,李俊,马陶陶.PI3K/Akt信号通路与肝纤维化[J].中国药理学通报,2011,27(8):1037-1041. |
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| 作者姓名： | 黄成 李俊 马陶陶 |
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| 作者单位： | 安徽医科大学药学院,安徽,合肥,230032 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | PI3K/Akt信号通路为细胞内重要信号传导通路之一,在促进细胞增殖、抑制凋亡的过程中发挥重要作用。PI3K/Akt信号通路与肝纤维化的发生、发展密切相关。通过干预PI3K/Akt信号通路,研究肝纤维化的发病机制和药物治疗是有意义的途径。该文就PI3K/Akt信号通路的构成、转导途径及其在肝纤维化中的作用作一综述。
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| 关 键 词： | 磷脂酰肌醇3激酶 肝纤维化 肝星状细胞 增殖 凋亡 细胞因子 |
PI3K/Akt signaling pathway and liver fibrosis |
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| HUANG Cheng,LI Jun,MA Tao-tao.PI3K/Akt signaling pathway and liver fibrosis[J].Chinese Pharmacological Bulletin,2011,27(8):1037-1041. |
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| Authors: | HUANG Cheng LI Jun MA Tao-tao |
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| Institution: | (College of Pharmacy,Anhui Medical University,Hefei 230032,China) |
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| Abstract: | Phosphatidylinositol 3-kinase/Akt(PI3K/Akt) signal pathway is an important intracellular signal transduction pathway.It plays important roles in inhibiting cell apoptosis and stimulating cell proliperation.PI3K/Akt signal transduction pathway is closely related to the occurrence and development of liver fibrosis.It is a promising way to study the pathogenesis and therapy of liver fibrosis through intervention of PI3K/Akt signaling pathway.This review briefly summarizes the PI3K/Akt pathway's structure,intracellular signaling cascades and its role in liver fibrosis. |
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| Keywords: | phosphatidylinositol 3-kinase liver fibrosis hepatic stellate cell proliferation apoptosis cytokine |
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