| 急性冠状动脉综合征患者基质金属蛋白酶-9来源的研究 |
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| 引用本文： | 陈少源,苏又苏. 急性冠状动脉综合征患者基质金属蛋白酶-9来源的研究[J]. 临床心血管病杂志, 2011, 27(6) |
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| 作者姓名： | 陈少源 苏又苏 |
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| 作者单位： | 广东医学院附属深圳南山医院心血管内科,广州深圳,518052 |
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| 摘 要： | 目的:探讨急性冠状动脉综合征(ACS)患者基质金属蛋白酶(MMP)-9的来源.方法:用ELISA法测定75例ACS、28例稳定型心绞痛(SAP)患者外周静脉、冠状动脉罪犯病变近远端血MMP-9水平,14例对照者(CG)则于外周静脉、主动脉根部和冠状静脉窦口采血.结果:①CG组和SAP组各部位血MMP-9水平差异无统计学意义;②ACS组静脉、罪犯病变近端和罪犯病变远端MMP-9水平差异有统计学意义,MMP-9水平病变远端>罪犯病变近端>静脉;③静脉和罪犯病变近端MMP-9水平ACS组显著高于CG和SAP组,而CG与SAP组差异无统计学意义;④罪犯病变远端MMP-9水平ACS组显著高于SAP组;⑤SAP和ACS组静脉MMP-9均与各自病变远端MMP-9水平正相关.结论:ACS患者MMP-9水平的升高主要来源于不稳定斑块的释放;静脉MMP-9可作为检测斑块不稳定的生物学标记物.
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| 关 键 词： | 冠状动脉疾病 急性冠状动脉综合征 基质金属蛋白酶-9 斑块 |
Source of MMP-9 in patients with acute coronary syndrome |
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| CHEN Shaoyuan,SU Yousu. Source of MMP-9 in patients with acute coronary syndrome[J]. Journal of Clinical Cardiology, 2011, 27(6) |
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| Authors: | CHEN Shaoyuan SU Yousu |
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| Affiliation: | CHEN Shaoyuan SU Yousu(Department of Cardiology,Nanshan Hospital,Guangdong Medical College,Shenzhen,518052,China) |
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| Abstract: | Objective:To examined the regional changes of MMP-9 in patients with ACS.Method:The 75 patients with ACS and 28 with stable angina pectoris(SAP) were included in the study.Blood of patients was aspirated from the culprit coronary artery and was also sampled from peripheral veins.Control samples were obtained from the peripheral blood,coronary sinus and aortic roots of age-matched subjects(CG).ELISA was used to assay plasma MMP-9.Result:There was no difference in plasma levels of MMP-9 between CG and SAP gro... |
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| Keywords: | coronary artery disease acute coronary syndrome matrix metalloproteinases-9 plaque |
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