槟榔中与烯丙基焦儿茶酚具有协同抗疟疾作用化合物的生物活性导向分离

目的:从槟榔中筛选出能与烯丙基焦儿茶酚具有协同抗疟疾的化合物。方法:运用生物活性导向分离的方法,把从槟榔的甲醇提取物中分离的各组分进行体外抗疟疾试验,找出活性单体。结果:筛选出能与烯丙基焦儿茶酚具有协同抗疟疾作用的两个化合物,他们与烯丙基焦儿茶酚在一定浓度下单独给药体外抗疟疾效果很差,但是联合给药具有较好的体外协同抗疟疾作用。

Bioassay guided isolation for principles from Semen Arecae possessing the anti-malaria synergistic effect with aUylpyrocatechol

Objective:To screen out the principles possessing the anti-malaria synergistic effect with allylpyrocatechol from Semen Arecae.Meth-od:Bioassay guided isolation was used to find out the monomeric compounds by carrying out the vitro anti-malaria assay on the fractions isola-ted from the MeOHextract of Semen Arecae.Results:Two compounds were screened out and showed the moderate synergistic effect of vitroanti-malaria activities with allylpyrocatechol under the concentration in which all of them showed very weak anti-malaria activities when theywere used alone.