| 石榴皮提取物对大鼠实验性结肠炎的保护作用 |
| |
| 引用本文： | 艾明仙,廖泽云,李玉山.石榴皮提取物对大鼠实验性结肠炎的保护作用[J].中药药理与临床,2007,23(5):122-124. |
| |
| 作者姓名： | 艾明仙 廖泽云 李玉山 |
| |
| 作者单位： | 湖北民族学院医学院,恩施,445000 |
| |
| 摘 要： | 目的:研究石榴皮对大鼠实验性结肠炎组织损伤的保护作用及其机制。方法:用三硝基苯磺酸建立大鼠实验性结肠炎模型,灌胃停药2周后评价大鼠结肠粘膜损伤指数(CMDI),检测结肠组织髓过氧化物酶(MPO)、超氧化物歧化酶(SOD)谷胱甘肽过氧化物酶(GSH-PX)活性和丙二醛(MDA)含量。结果:石榴皮200、400、800mg/kg灌胃能不同程度降低结肠炎模型大鼠CMD I、MPO活性,减少MDA含量,提高SOD、GSH-PX活性。结论:石榴皮对TNBS所致大鼠实验性结肠炎有明显保护作用。
|
| 关 键 词： | 石榴皮提取物 抗氧化作用 结肠炎 |
Effects of pomegranate peel extract on ulcerative colitis induced by TNBS in rats |
| |
| Ai Mingxian,Liao zeyun,LI Yushan.Effects of pomegranate peel extract on ulcerative colitis induced by TNBS in rats[J].Pharmacology and Clinics of Chinese Materia Medica,2007,23(5):122-124. |
| |
| Authors: | Ai Mingxian Liao zeyun LI Yushan |
| |
| Institution: | Medical School of Hubei Institute for Nationalities,Enshi 445000 |
| |
| Abstract: | Objective:To study the protect effect of pomegranate peel extract on the colonic tissue with ulcerative colonitis induced by trinitrobenzene sulfonic acid(TNBS)in rats.Methods:Rat model of ulcerative colonitis was established by clyster of TNBS.After treatment with pomegranate peel for two weeks,the colon mucosal damage index(CMDI) was evaluated,the activity of myeloperoxidase(MPO),superoxide dismutase(SOD),glutathione peroxidase(GSH-PX) and the content of malondialdehyde(MDA) in the colon tissues were examined.Results: Pomegranate peel extract(200,400,800mg/kg)can decrease the values of CMDI,the activity of MPO and the content of MDA,increase the activity of SOD and GSH-PX in a dose-depended manner.Conclusion: Pomegranate peel extract can relieve the inflammatory reaction and colonic injury in colonitis rats by anti-oxidation and wound repair. |
| |
| Keywords: | pomegranate peel extract colonitis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
