Effect of bombesin (6–14) on arterial pressure in health and in hypovolemic shock |
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| Authors: | A T Mar'yanovich V N Tsygan Yu I Shipilov M A Signaevskii S I Churkina |
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| Institution: | (1) Department of Normal Physiology, Laboratory of Physiology, of Extremal States, Academy of Military Medicine, St. Petersburg, USSR;(2) Department for the Chemistry of Naturally Occurring Compounds, St. Petersburg State University, St. Petersburg, USSR |
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| Abstract: | Injection of active fragment of the neuropeptide bombesin (6–14) into cerebral ventricles of intact rabbits induces marked
arterial hypertension accompanied by bradycardia and partial redistribution of blood to specialized heat-emitting organs (auricular
conchae), which reduces body temperature. After a considerable blood loss, the peptide normalizes arterial pressure without
affecting cardiac activity and body temperature. It is suggested that bombesins may be used for compensation of arterial hypotension
during the early period of hypovolemic shock.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 10, pp. 372–374, October, 1996 |
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| Keywords: | arterial pressure blood loss bombesin |
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