| 人类白细胞抗原群体遗传学研究 |
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| 引用本文： | 缪扣荣,汪承亚. 人类白细胞抗原群体遗传学研究[J]. 中华医学遗传学杂志, 2007, 24(5): 548-550 |
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| 作者姓名： | 缪扣荣 汪承亚 |
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| 作者单位： | 南京医科大学第一附属医院HLA实验室,210029 |
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| 摘 要： | 人类白细胞抗原(human leukocyte antigen,HLA)系统是人类最复杂的遗传多态性系统。HLA群体遗传学的研究,一方面可揭示不同地区、不同民族的人群HLA分布情况,进行人群遗传学分析;另一方面有助于HLA与疾病相关性的研究以及为寻找HLA相合造血干细胞供者提供基础性资料。本文就HLA分子遗传基础、HLA群体遗传的内容及研究方法进展作一综述。
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| 关 键 词： | 人类白细胞抗原 群体遗传学 单倍型 |
| 修稿时间： | 2006-12-18 |
The population genetics study in HLA field |
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| MIAO Kou-rong,WANG Cheng-ya. The population genetics study in HLA field[J]. Chinese journal of medical genetics, 2007, 24(5): 548-550 |
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| Authors: | MIAO Kou-rong WANG Cheng-ya |
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| Affiliation: | HIM Laboratory, the First Affdi- ated Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210029 P. R. China |
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| Abstract: | Human leukocyte antigen(HLA) is the most polymorphic genetic system found in human genome.The polymorphisms of different HLA genes and haplotypes in different ethnic and geographic populations are of high importance for investigation of their population genetic characteristics and searching for HLA matched unrelated hematopoietic stem cell transplantation donors,as well as in disease association studies.The HLA molecular genetic principals and the progress of HLA population investigation were reviewed,as well as the methods applied in the field. |
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| Keywords: | human leukocyte antigen population genetics haplotype |
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