| HLA-DRBl＊04等位基因多态性与乙型肝炎病毒感染结局关联分析 |
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| 引用本文： | 宋明胜,李红卫,彭怀燕,段炳南,陈辉,徐令清.HLA-DRBl＊04等位基因多态性与乙型肝炎病毒感染结局关联分析[J].中华医学遗传学杂志,2007,24(4):467-469. |
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| 作者姓名： | 宋明胜 李红卫 彭怀燕 段炳南 陈辉 徐令清 |
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| 作者单位： | [1]中南大学湘雅三医院检验科,长沙410013 [2]湘雅医学院组织胎学教研室,长沙410013 |
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| 基金项目： | 湖南省自然科学基金（02JJY3018） |
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| 摘 要： | 目的从分子遗传学角度探讨乙型肝炎病毒（hepatitis B virus，HBv）感染结局与GLA—DRBl＊04等位基因的相关性。方法采用聚合酶链反应一序列特异性引物（polymerase chain reaction-sequence specific primers，PCR-SSP）技术检测HLA-DRBl＊04等位基因，并比较106例无症状HBV携带者（HBV携带组），93例慢性乙型肝炎患者、77例乙肝肝硬化者、102例HBV感染后自然恢复者（对照组）HIA-DRBl＊04等位基因频率及HBV不同复制状态下HLA-DRBl＊04等位基因频率。结果HBV携带组、慢性乙肝组、乙肝肝硬化组HLA-DRBl＊04等位基因频率高于对照组（分别为25．94％、26．34％、27．92％和14．22％，P〈0．01）；HLA—DRBl＊0401基因频率高于对照组（分别为20．91％、24．49％、22．09％和8．62％，P均〈0．05）；HLA-DRBl＊0405基因频率较对照组低（3．64％、2．04％、3．49％和15．52％，P〈0．01、0．01、0．05）。各病例组之间HLA—DRBl＊04等位基因频率差异无统计学意义（P〉0．05）。HBV不同复制状态HLA-DRBl＊04等位基因频率差异无统计学意义（P〉O．05）。结论HLA-DRBl＊04是决定HBV感染结局的因素之一，但不影响HBV在体内复制。
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| 关 键 词： | 乙型肝炎 遗传多态性 人类白细胞抗原-DRBl＊04 |
| 修稿时间： | 2006-08-21 |
Association of polymorphism on HLA-DRB1*04 alleles with outcome of hepatitis B virus infection] |
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| SONG Ming-sheng, LI Hong-wei, PENG Huai-yan, DUAN Bing-nan, CHEN Hui, XU Ling-qing. ;.Association of polymorphism on HLA-DRB1*04 alleles with outcome of hepatitis B virus infection][J].Chinese Journal of Medical Genetics,2007,24(4):467-469. |
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| Authors: | SONG Ming-sheng LI Hong-wei PENG Huai-yan DUAN Bing-nan CHEN Hui XU Ling-qing ; |
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| Institution: | Department of Clinical Laboratory, the Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013 P. R. China.;Department of Histology and Embryology, Xiangya Medical College, Central South University, Changsha, Hunan, 410013 P. R. China |
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| Abstract: | OBJECTIVE: To investigate the relation between the alleles of HLA-DRB1*04 and outcome of HBV infection. METHODS: The alleles of HLA-DRB1*04 were detected by polymerase chain reaction-sequence specific primer (PCR-SSP). The frequency of allele of HLA-DRB1*04 in four groups106 asymptomatic HBsAg carriers (group ASC), 93 chronic hepatitis B patients (group CHB), 77 patients with hepatitis B cirrhosis and 102 cases of spontaneous recovery after HBV infection (control group)] were studied, and the frequency of that in different replication of HBV was also studied. RESULTS: The frequency of allele of HLA-RB1*04 in groups ASC, CHB and hepatitis B cirrhosis was markedly higher than that of control group (25.94%, 26.34%, 27.92% respectively versus 14.22%, P< 0.01); the frequency of HLA-DRB1*0401 in groups ASC, CHB and hepatitis B cirrhosis was also higher than that of control group (20.91%, 24.49%, 22.09% respectively versus 8.62%, P< 0.05, P< 0.01,P< 0.05 respectively); the frequency of HLA-DRB1*0405 in groups ASC, CHB and hepatitis B cirrhosis was lower than that of control group (3.64%, 2.04%, 3.49% respectively versus 15.52%, P< 0.01, P< 0.01, P< 0.05 respectively ). There was no statistical significance in the allele frequency of HLA-DRB1*04 among groups ASC, CHB and hepatitis B cirrhosis (P> 0.05), and the same result was observed in different replication of HBV (P> 0.05). CONCLUSION: HLA-DRB1*04 gene is one of the factors which determine the outcomes of HBV infection, while it has no influence on HBV replication. |
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