| 硫酸软骨素和玻璃酸钠联合应用治疗木瓜酶致兔膝骨关节炎 |
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| 引用本文： | 陈磊,凌沛学,贺艳丽,张天民. 硫酸软骨素和玻璃酸钠联合应用治疗木瓜酶致兔膝骨关节炎[J]. 中国生化药物杂志, 2009, 30(1) |
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| 作者姓名： | 陈磊 凌沛学 贺艳丽 张天民 |
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| 作者单位： | 山东大学药学院,山东济南,250012;山东省生物药物研究院博士后科研1-作站,山东,济南,250108 |
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| 摘 要： | 目的研究关节腔内注射硫酸软骨素和玻璃酸钠组合物治疗木瓜酶致兔膝骨关节炎的疗效和机制。方法新西兰兔12只,左右膝关节腔内各注射0.4%木瓜酶溶液0.3 mL,随机分为4组。自造模7 d后开始给药,每周1次,共5周。结果硫酸软骨素和玻璃酸钠联用组疗效优于生理盐水组。关节腔内注射酸软骨素和玻璃酸钠能够明显促进滑膜、软骨细胞增生,促进滑膜中血管增生,降低软骨破坏和滑膜纤维增生,同时抑制白介素-1β的分泌,有效的降低NO自由基的含量,有利于改善骨关节炎症状。结论硫酸软骨素和玻璃酸钠联用是一种有效的治疗骨关节炎的方法。
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| 关 键 词： | 硫酸软骨素 玻璃酸钠 骨关节炎 NO |
Study on intra-articular sodium hyaluronate and chondroitin sulfate injections in treating knee osteoarthritis of rabbits |
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| CHEN Lei,LING Pei-xue,HE Yan-li,ZHANG Tian-min. Study on intra-articular sodium hyaluronate and chondroitin sulfate injections in treating knee osteoarthritis of rabbits[J]. Chinese Journal of Biochemical Pharmaceutics, 2009, 30(1) |
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| Authors: | CHEN Lei LING Pei-xue HE Yan-li ZHANG Tian-min |
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| Affiliation: | 1.School of Pharmaceutical Science;Shandong University;Jinan 250012;China;2.Working Station forPostdoctoral Scientific Research;Institute of Biopharmaceuticals of Shandong Province;Jinan 250108;China |
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| Abstract: | Purpose To investigate the effects and mechanisms of intra-articular sodium hyaluronate and chondroitin sulfate injections in treating rabbit osteoarthritis.Methods The twelve rabbits were randomly divided into four groups after the model of osteoarthritis was established by injecting 0.3 mL of 0.4 % papain into knee joint cavities of the rabbits.The four groups received intra-articular injection weekly for 5 weeks after 7 days respectively.Results The curative effect of sodium hyaluronate and chondroitin s... |
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| Keywords: | NO |
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