2型糖尿病白蛋白尿与颈动脉内中膜厚度的关系探讨 |
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引用本文: | 于海雁,谢云.2型糖尿病白蛋白尿与颈动脉内中膜厚度的关系探讨[J].天津医药,2010,0(11):957. |
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作者姓名: | 于海雁 谢云 |
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作者单位: | 天津医科大学代谢病医院5楼病房 |
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摘 要: | 目的:探讨2型糖尿病患者白蛋白尿与颈动脉内中膜厚度的关系。方法:将146例2型糖尿病(type 2 diabetes mellitus,T2DM)患者行24小时尿微量白蛋白检测,根据结果分为正常白蛋白尿组(86例)和异常白蛋白尿组(60例)(包括微量白蛋白尿组和大量白蛋白尿组),对两组患者分别进行各项生化指标及颈动脉内中膜厚度(intima-media thickness,IMT)的检测,并对两组数据进行单因素、多因素logistic回归分析,进一步经方差分析比较正常尿、微量白蛋白尿(micro - albuminuria,MAU)以及大量白蛋白尿三组间颈动脉IMT的差异。结果:①单因素logistic回归显示病程、视网膜病变发生率、甘油三酯(triglyceride,TG)、颈动脉IMT和血肌酐(creatinine,Cr)是2型糖尿病白蛋白尿的危险因素;②多因素logistic回归示病程长、甘油三酯高、颈动脉内中膜厚度增厚、血肌酐增高是2型糖尿病患者白蛋白尿的独立危险因素(OR值分别为 1.105,1.528.12.781,1.029)。③方差分析结果显示: 正常白蛋白尿组、微量白蛋白尿组、大量白蛋白尿组三组间颈动脉IMT均数比较,差异有统计学意义(P=0.000),而微量白蛋白尿组与大量白蛋白尿组之间比较差异无统计学意义(P=0.805)。结论:2型糖尿病患者颈动脉IMT是白蛋白尿的一个独立危险因素(OR=12.871),糖尿病肾病的严重程度与颈动脉IMT无明显相关性(P=0.805)。
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关 键 词: | 2型糖尿病 颈动脉内中膜厚度 糖尿病肾病 微量白蛋白尿 白蛋白尿 |
收稿时间: | 2010-01-25 |
修稿时间: | 2010-04-20 |
Discussion of the relationship between albuminuria and carotid artery intima-media thickness in type 2 diabetes mellitus |
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Abstract: | to discuss the relationship between albuminuria and carotid artery intima-media thickness (IMT) in type 2 diabetes mellitus.Methods: 146 type 2 diabetes mellitus (T2DM) patients with 24-hour urine microalbumin detection,who based on the results were divided into normal albuminuria group (86 cases) and abnormal albuminuria group (60 cases) (including micro - albuminuria(MAU) group and macroalbuminuria group) .Two groups of patients were carried out on various biochemical indices and carotid artery intima-media thickness (IMT) detection, and two sets of data were analyzed by the single factor, multi-factor logistic regression analysis.Further compare the difference of carotid IMT among the three groups of normal urine, microalbuminuria and macroalbuminuria by variance analysis. Results: ①Single-factor logistic regression analysis showed that duration, the incidence of retinopathy, triglyceride (TG), carotid artery intima-media thickness (IMT) and serum creatinine (Cr) were the risk factors of albuminuria; ②multi-factors logistic regression showed longer duration, higher triglycerides, carotid artery intima-media thickness thickening, increased serum creatinine in patients with type 2 diabetes were the independent risk factors of albuminuria.(the OR values were 1.105,1.528,12.781,1.029respectively).③variance analysis showed: Among the three groups including normal albuminuria group, microalbuminuria group, macroalbuminuria, the difference of carotid artery IMT was statistically significant (P = 0.000), while there were no statistically significant difference between the groups of microalbuminuria and macroalbuminuria (P = 0.805). Conclusion: In patients with type 2 diabetes, carotid artery IMT is an independent risk factor of albuminuria(OR = 12.871), while the severity of diabetic kidney disease and carotid IMT was no significant correlation (P = 0.805). |
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Keywords: | type 2 diabetes mellitus intima-media thickness diabetic nephropathy microalbuminuria albuminuria |
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