冻融胚胎移植周期患者年龄、移植胚胎个数与妊娠结局关系的研究

摘要 目的：探讨冻融周期年龄、移植胚胎个数与妊娠结局的关系。方法：对本中心2005-2008年进行的解冻移植周期中可供移植的 1052个周期按年龄分为≤34岁为A组、35-39岁为B组、≥40岁为C组，按移植胚胎个数分为单胚胎移植为D组、2个胚胎移植为E组、3个胚胎移植为F组，分别分析年龄、移植胚胎个数与FET结局的关系。结果：A组与B组着床率无统计学差异（P＞0.05），但均高于C组（P＜0.05）。Ａ组与Ｂ组流产率有统计学差异（P＜0.05）。D组妊娠率与E、F组有统计学差异（P＜0.05）。E组多胎率25.1%与F组44.7%有统计学差异（P＜0.05），D组无多胎发生。E组减胎率3.4%与F组13.1%有统计学差异（P＜0.05）。D组、E组、F组间宫外孕率均无统计学差别（P＞0.05）。结论：≥40岁患者着床率显著降低，增加移植胚胎个数不能提高妊娠率。宫外孕、流产与移植胚胎个数无关。冻融周期移植两个胚胎是合理的选择，而选择性单胚胎移植是一个新的方向。

The research of age and transferred embryo's number on pregnancy outcomes in infertile patients undergoing FET

ABSTRACT Object:To investigate the effects of age and the number of embryo transferred on pregnancy outcomes in infertile patients undergoing FET.Methods:A retropective analysis was performed in our center on the clinical data of 1052 thawing cases from Jan. 2004 to December 2008 .Results:The implantation rate was significantly lower in A group compared with those of B group(P＜0.05), but higher than that C group (P <0.05). The abortion rate was significantly lower in A group compared with those of B group(P＜0.05).There were significant differences in multiple pregnancy rate and fetal reduction rate between E group and F group. Ectopic pregnancy rate among groups were no difference (P> 0.05). Conclusion: Patients ≥40yrs implantation rate decreased significantly.The number of transferred embryos has nothing to do with ectopic pregnancy and abortion rate occurs. Transplantation 2 embryos is the reasonable choice and elective single embryo transfer(eSET) is a new choice .