| 丝烈霉素C诱发小白鼠骨髓细胞姐妹染色单体互换和染色体畸变 |
| |
| 引用本文： | 卢尧,刘冰,李冬娜,庞惠民. 丝烈霉素C诱发小白鼠骨髓细胞姐妹染色单体互换和染色体畸变[J]. 吉林大学学报(医学版), 1987, 0(5) |
| |
| 作者姓名： | 卢尧 刘冰 李冬娜 庞惠民 |
| |
| 作者单位： | 白求恩医科大学医学遗传教研室(卢尧，刘冰，李冬娜)，白求恩医科大学医学遗传教研室(庞惠民) |
| |
| 摘 要： | 丝裂霉素C(MMc)诱导的姐妹染色单体互换(SCE)可反映出细胞DMA损伤修复的基本过程。有关MMC诱发活体的SCE研究不多。本实验目的,就是探讨MMC诱发小白鼠骨髓细胞SCE的剂量—效应关系,并对SCE指标与染色体畸变指标,在检测机体DNA损伤上的差异作一比较研究。结果证明,MMC诱发染色体畸变能办远低于诱发SCE的能力,MMC可诱发小白鼠骨髓细胞SCE产生,SCE值随MMC剂量的增加而增加。SCE即使在低剂量诱变剂的作用下也是敏感的。
|
| 关 键 词： | 丝裂霉素C 小白鼠骨髓细胞姐妹染色单体互换 染色体畸变 |
Induction of sister chromatjd exchanges'''' and chromosome aberration in mouse bone marrow cells with mitomycjn C |
| |
| Lu Yao,Liu Bing,Li Dongna and Pang Huimin. Induction of sister chromatjd exchanges'''' and chromosome aberration in mouse bone marrow cells with mitomycjn C[J]. Journal of Jilin University: Med Ed, 1987, 0(5) |
| |
| Authors: | Lu Yao Liu Bing Li Dongna Pang Huimin |
| |
| Abstract: | Sister chromatid exchange (SCE) reflects the basic course of repairing process of DNA injuries induced by mitomycin C (MMC) .Accordingly, the authors studied the dose-effect relationship of SCE in mouse bone marrow cells, using MMC as the inducing agent and comparing the sensitivity of SCE and chromosomal aberration as parameters in the detection of DNA injuries. The results showed that the potentiality of MMC in inducing chromosomal aberrations was much lower than that in inducing SCE. The frequency of SCE increased with an increase in dosage of MMC. SCE was sensitive even when the inducing agent was in low doses. |
| |
| Keywords: | Mitomycin C (MMC) Mouse bone marrow cells Sister chromatid exchange (SCE) Chromosome aberration |
| 本文献已被 CNKI 等数据库收录！ |
