图像引导放疗同步NP方案化疗治疗局部晚期非小细胞肺癌的近期疗效观察

目的评价局部晚期非小细胞肺癌（NSCLC）接受放化疗综合治疗的结果。方法 50例局部晚期非小细胞肺癌患者接受图像引导放疗联合NP方案化疗模式治疗。化学治疗方案采用NP方案（N：国产长春瑞滨,25 mg/m2,第1、8天使用;P：顺铂,25 mg/m2,第2～4天使用;28 d为1个周期）,化疗从放疗开始第1天起同期应用,分别于第1、5周给予,放疗结束后巩固1个周期,共3个周期。图像引导放疗方法应用医科达Synergy医用直线加速器行图像引导放疗。中位放疗剂量62 Gy（55～69 Gy）。结果 50例患者完全缓解6例,部分缓解34例,稳定6例,进展4例,总有效率为80%。1年生存率为74%,4例（8%）患者出现NC I CTC≥3级放射性肺炎,16例（32%）患者出现放射性食管炎（Ⅰ～Ⅱ级）。结论图像引导放疗联合NP方案可获得较好的临床治疗效果,不良反应可以耐受。

Short-term efficacy of vinorelbine plus cisplatin combined with image guided radiotherapy for locally advanced non-small cell lung cancer

Objective To evaluate the acute side and clinical afficacy of vinorelbine plus cisplatin combined with image guided radiotherapy(IGRT) for locally advanced non-small cell lung cancer(NSCLC).Methods Fifty patient with locally advanced NSCLC were given vinorelbine 25 mg/m2 by intravenous infusion on day 1,and DDP 25 mg/m2 by intravenous infusion on day 2-4,at the same time,they received IGRT to total dose of 62 Gy/35 f.Results The response rate(RR) was 80%.The one-year survival rate was 74%,4 patients(8%) had...