Drug metabolism in rats with arthritis induced by 6-sulfanilamidoindazole (6-SAI) |
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| Authors: | D Müller R Hirschelmann |
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| Institution: | (1) Institute of Pharmacology and Toxicology, Friedrich Schiller University Jena, Löbderstr. 1, DDR-6900 Jena;(2) Department of Pharmacology, Pharmacy Section, Martin Luther University Halle-Wittenberg, Weinbergweg 15, DDR-4020 Halle, German Democratic Republic |
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| Abstract: | Hexobarbital sleeping time was prolonged and ethylmorphine N-demethylation was inhibited after a single dosage or seven administrations of 6-SAI to old rats. These effects were independent of the development of arthritis. Changes in cytochrome P-450 concentration after 6-SAI treatment were insignificant and thus not responsible for the decrease in drug metabolism.In vitro 6-SAI inhibited ethylmorphine N-demethylation; the inhibition was of a mixed type. 6-SAI bound to cytochrome P-450 and induced a type II spectrum. The magnitude of hexobarbital-induced type I spectral changes was diminished by 6-SAI.It is concluded that 6-SAI inhibits cytochrome P-450-dependent drug metabolism by binding to cytochrome P-450. |
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