精神分裂症患者伴发代谢综合征的相关因素

目的:探索住院精神分裂症患者伴发代谢综合征的相关因素。方法:抽取5个地区5家医院的住院精神分裂症患者,调查伴发代谢综合征的相关因素。内容包括:年龄、病程、精神病药物与剂量、空腹血糖、血脂等。结果:资料完整的797例住院精神分裂症患者,伴发代谢综合征者共153例(19．2％)。病程长、服用氯氮平、服用药物时间长、高剂量用药患者MS发生率高(P<0．05、P<0．01);L0gistic回归分析显示:代谢综合征的危险因素有高龄、服用氯氮平、CRP浓度偏高、吸烟、服用抗精神病药物时间长。结论:影响住院精神分裂症患者伴发代谢综合征的相关因素有氯氮平、病程、用药时间、吸烟等。

Factors Related to Hospitalized Schizophrenics with Metabolic Syndrome

Objective:To explore the relative factors of hospitalized schizophrenics with metabolic syndrome. Methods: Patients data were collected by the way of face-to-face questionnaire to patients or their guardians, consulting patients medical record, checking physical or laboratory examination. Information include age, duration of the disease, the classification of antipsychotics and dosage, fast plasma glucose, plasma lipids, blood pressure, etc of hospitalized schizophrenics. The relative factors of metabolic syndrome were analyzed. Results; Among 797 schizophrenics, there were 153 cases (19. 2% ) suffered from metabolic syndrome. Single-factor analysis showed that the patients with longer duration of the disease, taking clozapine, etc, were at high risk of metabolic syndrome, and sex didnt relate to metabolic syndrome; Logistic regression analysis appeared that metabolic syndrome correlated with age, clozapine, CRP concentration, etc. Conclusion: The possible risk factors causing metabolic syndrome in schizophrenia include, duration of the disease, etc.