| 膜1型基质金属蛋白酶在骨代谢作用中的研究进展 |
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| 引用本文： | 冯小力,裴启霖王霞王彬. 膜1型基质金属蛋白酶在骨代谢作用中的研究进展[J]. 中国骨质疏松杂志, 2021, 0(8): 1213-1217 |
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| 作者姓名： | 冯小力 裴启霖王霞王彬 |
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| 作者单位： | 1重庆医科大学生命科学研究院,重庆 4000162重庆医科大学附属儿童医院,重庆 400014 |
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| 基金项目： | 国家自然科学基金（11602046）;重庆市渝中区基础研究与前沿探索项目（20190114）;重庆医科大学生命科学研究院大学生科学研究与创新实验项目（201901） |
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| 摘 要： | 基质金属蛋白酶是一类锌依赖性内肽酶,可降解大多数细胞外基质.膜1型基质金属蛋白酶(membrane type-1 matrix metalloproteinase,MT1-MMP或MMP14)属于基质金属蛋白酶家族,是唯一一种能够直接促进细胞向3 D胶原蛋白基质入侵的胶原酶.骨细胞胞外基质在骨形成和骨吸收过程中发挥重要...
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| 关 键 词： | 膜1型基质金属蛋白酶 骨代谢 骨形成 骨吸收 |
Research progress of membrane 1 matrix metalloproteinase in bone metabolism |
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| FENG Xiaoli,PEI Qilin,WANG Xi,WANG Bin. Research progress of membrane 1 matrix metalloproteinase in bone metabolism[J]. Chinese Journal of Osteoporosis, 2021, 0(8): 1213-1217 |
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| Authors: | FENG Xiaoli PEI Qilin WANG Xi WANG Bin |
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| Affiliation: | 1.Institute of Life Sciences, Chongqing Medical University, Chongqing 4000162.Children''s Hospital of Chongqing Medical University, Chongqing 400014,China |
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| Abstract: | Matrix Metalloproteinases (MMPs) are a type of zinc-dependent endopeptidases, which can degrade most of the extracellular matrix metalloproteinases. Membrane type-1 matrix metalloproteinase (MT1-MMP) is a unique MMP, as the collagenase to promote cell invasion into 3D collagen matrix directly. Extracellular matrix (ECM) plays an important role in the process of bone formation and bone absorption. MT1-MMP can induce the bone-related pathological and physiological changes via ECM. This article intends to review the research progress of MT1-MMP in bone metabolism in recent years, aiming to provide new ideas for pharmacological intervention of MT1-MMP in anti-bone resorption and its application in bone bioengineering. |
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| Keywords: | MT1-MMP bone metabolism bone formation bone resorption |
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