血清催产素浓度与绝经后女性骨密度相关性研究

目的探讨催产素与绝经后妇女骨代谢指标以及腰椎和髋部骨密度之间相关性。方法检测185例骨密度正常和132例患骨质疏松症女性的血清催产素、瘦素、雌激素和骨代谢指标浓度。腰椎和股骨颈的BMD通过双能X线吸收法测量。结果患骨质疏松症女性的血清催产素浓度低于骨密度正常的女性(P0.05)。骨质疏松症组中血清催产素浓度与年龄、绝经年限、体质量指数(body mass index,BMI)和血清PINP、BLAP和CTX浓度呈负相关;与瘦素和雌激素具有明显正相关性;在正常骨密度组中,血清催产素浓度和各种指标未发现明显的相关性。调整年龄和BMI后,腰椎和股骨颈骨密度仍然与绝经年限以及血清PINP、BLAP和CTX浓度呈负相关,与雌激素、瘦素和催产素浓度呈正相关。对年龄和BMI进行调整后,进行多元回归分析显示绝经年限、血清催产素、PINP和CTX是腰椎和股骨颈骨密度的显著预测因子。结论绝经后女性患者较高的血清催产素水平与较高的腰椎和股骨颈骨密度有关。

The relationship between serum oxytocin concentration and bone mineral density in postmenopausal women

Objective To explore the correlation between oxytocin and bone metabolism and bone mineral density of lumbar vertebrae and hip in postmenopausal women. Methods the concentrations of serum oxytocin, leptin, estrogen and bone metabolic markers were measured in 185 cases of normal bone mineral density and 132 cases of osteoporosis. The BMD of lumbar vertebrae and femoral neck were measured by dual energy X-ray absorptiometry. The relationship between oxytocin level and bone mineral density was explored. Results The serum oxytocin concentration in the osteoporotic women was lower than that in the normal bone mineral density women (P<0.05). In osteoporosis group, serum oxytocin concentration was negatively correlated with age, menopausal years, BMI, serum PINP, BLAP and CTX, and positively correlated with leptin and estrogen. In normal bone mineral density group, no significant correlation was found between serum oxytocin concentration and various indexes. After adjusting age and BMI, the BMD of lumbar vertebrae and femoral neck was still negatively correlated with the years of menopause and the concentrations of serum PINP, BLAP and CTX, and positively correlated with the concentrations of estrogen, leptin and oxytocin. After adjusting for age and BMI, multiple regression analysis showed that years of menopause, serum oxytocin, PINP and CTX were significant predictors of bone mineral density of lumbar vertebrae and femoral neck. Conclusion The level of serum oxytocin in postmenopausal women is related to high bone mineral density of lumbar vertebrae and femoral neck.