| DNA芯片技术在药物研究中的应用 |
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| 引用本文： | 顾大勇. DNA芯片技术在药物研究中的应用[J]. 国际生物医学工程杂志, 2004, 27(3): 129-131 |
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| 作者姓名： | 顾大勇 |
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| 作者单位： | 400042,重庆,第三军医大学大坪医院野战外科研究所分子生物学中心 |
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| 基金项目： | 军队“十五”医药卫生科研基金重点课题(01Z073) |
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| 摘 要： | DNA芯片技术是21世纪生物技术的重要发展,是生命科学与物理学、化学、微电子学以及计算机学等学科相互交叉的一门高新技术。该技术的突出特点在于其高度的并行性、多样化、微型化、自动化,已在生物医学的各个领域显示出了巨大的发展潜力和应用价值。其中药物研究领域是其应用最广泛的领域之一,通过DNA芯片技术可以将药物的生物效应和基因变化密切相联系,从而为药物的研究、开发注入新的生机和活力。
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| 关 键 词： | DNA芯片 药物筛选 药物基因组学 药物毒理学 |
| 文章编号： | 1001-1110(2004)03-0129-04 |
| 修稿时间： | 2003-10-09 |
The application of DNA chip technology in the research of drug |
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| GU Da-yong . Moleuclar Biology Center,Research Institute of Surgery and Daping Hospital,The Third Military Medical University,Chongqing ,China. The application of DNA chip technology in the research of drug[J]. International Journal of Biomedical Engineering, 2004, 27(3): 129-131 |
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| Authors: | GU Da-yong . Moleuclar Biology Center Research Institute of Surgery Daping Hospital The Third Military Medical University Chongqing China |
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| Affiliation: | GU Da-yong . Moleuclar Biology Center,Research Institute of Surgery and Daping Hospital,The Third Military Medical University,Chongqing 400042,China |
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| Abstract: | DNA chip technology is a great development of biotechnology in the 21 century. It is a high-new technology and a reciprocal chiasmatic science between life science and physics, chemistry, micro-electronics, computer science and so on. This technology has many outstanding traits, such as parallelity, diversification, micromation, automatization. The technology has been applied to many fields of biomedicine, especially drug research. By this technology, the bio-effects of drugs would be related with the changes of genes which then will be helpful to further studies on drug. |
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| Keywords: | DNA chip drug screening pharmacogenomics drug toxicology |
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