妊娠期肝内胆汁淤积症与胎儿生长受限关系的临床探讨

目的：探讨妊娠期胆汁淤积症与胎儿生长受限之间的关系。方法：对我院分娩的80例ICP患者作为研究对象,并选择同期分娩的80例非ICP孕妇作为对照组,进行回顾性分析。结果：ICP组的新生儿羊水粪染率32.5%,胎儿窘迫率26.3%,早产率12.5%,窒息率10.0%,均高于同期分娩的对照组（P〈0.01或〈0.05）。ICP组的胎儿生长受限发生率为10.0%,新生儿平均体重为3255.18±466.14g,与对照组相比差异无统计学意义（P〉0.05）。多元线性回归分析,新生儿体重与孕妇肝功能无明显线性相关。结论：妊娠期肝内胆汁淤积症与胎儿生长受限无明显相关性。

THE CLINICAL ANALYSIS OF THE RELATIONSHIP BETWEEN THE INTRAHEPATIC CHOLESTASIS PREGNANCY AND FETAL RETARDATION

Objective：to investigate the relationship between the intrahepatic cholestasis pregnancy（ICP） and fetal growth retardation（FGR）.Methods：Totally 80 cases of ICP in our hospital were retrospectively reviewed and 80 cases of normal pregnant women as controls.Results：The incidence of meconium-stained amniotic fluid was 32.5%,fetal distress 26.3%,preterm labor 12.5%,and asphyxia 10.0%,all of which were significantly higher than those in the control group（P〈0.05）.The incidence of FGR in ICP group was 10.0% while the mean weight of neonate was 3255.18±466.14g. There were no significant differences in the mean weight of neonate and FGR between two groups （ P 〉 0.05 ）. There was no relationship between the weight of neonate and maternal liver functions by multi - factor lineal analysis. Conclusion： There is no adverse effect of ICP on the fetal growth.