| 妊娠免疫耐受机制的研究进展 |
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| 引用本文： | 孙风艳,王萍萍,田花香,王增艳[综述],胡吉英,王增芳[审校].妊娠免疫耐受机制的研究进展[J].医学综述,2013(22):4054-4057. |
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| 作者姓名： | 孙风艳 王萍萍 田花香 王增艳[综述] 胡吉英 王增芳[审校] |
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| 作者单位： | [1]潍坊市妇幼保健院妇产科,山东潍坊261000 [2]诸城市人民医院麻醉科,山东诸城262210 |
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| 摘 要： | 妊娠是一个复杂而又协调的生理过程，母一胎界面正常免疫耐受的建立和维持是妊娠成功与否的关键。母体胎盘、激素水平、黏附分子、细胞因子、人类白细胞抗原、自然杀伤细胞、调节性T淋巴细胞等在母一胎免疫耐受过程中均有重要作用。此外，吲哚胺2，3-双加氧酶作为一种分解代谢酶，其自身的表达调控及其与多种免疫因子、免疫细胞的相互作用在妊娠免疫耐受中也发挥着重要而复杂的作用。
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| 关 键 词： | 吲哚胺2，3-双加氧酶 色氨酸 妊娠 T细胞 免疫耐受 |
I Research Progress of the Mechanism in Immune Tolerance during Pregnancy |
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| Institution: | SUN Feng-yanI, WANG Ping-pingI , TIAN Hua-xiang1 , WANG Zeng-yan2 ,HU Ji-yingI , WANG Zeng-fang1. ( 1. Department of Gynecology and Obstetrics, Weifang Hospital of Maternal and Child Health, Weifang 261000, China; 2. Department of Anesthesia, Zhucheng People s Hospital, Zhucheng 262210, China) |
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| Abstract: | Pregnancy is a complex and harmonious physiological process. The establishment and mainte- nance of maternal-fetal immunological tolerance is critical for normal pregnancy. The maternal placenta,level of hormones, adhesion molecule, cytokines human leukocyte antigen natural killer cell and regulatory T cell play important roles in maternal-fetal immunological tolerance. Additionally, the indoleamine 2,3-dioxygen- ase a catabolic enzyme, exerts vital and complex effects on maternal-fetal tolerance by regulating its self- expression and interactions with a variety of immune molecules and ceils. |
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| Keywords: | Indoleamine 2 3-dioxygenase Tryptophan Pregnancy T ceil Immune tolerance |
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