| 脑卒中合并心房颤动的rt-PA溶栓及抗凝治疗的研究现状 |
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| 引用本文： | 林玲玲,黄银辉[综述],林友榆,蔡若蔚[审校]. 脑卒中合并心房颤动的rt-PA溶栓及抗凝治疗的研究现状[J]. 医学综述, 2013, 0(22): 4112-4115 |
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| 作者姓名： | 林玲玲 黄银辉[综述] 林友榆 蔡若蔚[审校] |
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| 作者单位： | [1]解放军第180医院神经内科,福建泉州362000 [2]福建医科大学附属第二医院晋江分院神经内科,福建晋江362000 [3]福建医科大学附属第二医院神经内科,福建泉州362000 |
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| 摘 要： | 脑卒中是老年人群中致死、致残的主要原因，与脑卒中发生相关的最常见的心脏病是心房颤动（房颤）。约2／3合并房颤的脑卒中患者，其脑卒中的发生是由心源性栓子导致的。脑卒中合并房颤在无溶栓禁忌证时重组组织型纤溶酶原激活物溶栓治疗是安全、有效的，但疗效较无合并房颤患者差；在有溶栓禁忌证时，抗凝治疗为预防脑卒中合并房颤患者再次栓塞最有效的二级预防措施。新抗凝药物达比加群将成为华法林的有力替代者。
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| 关 键 词： | 脑卒中 心房颤动 溶栓 抗凝 |
Research Status of rt-PA Thrombolytic Therapy and Anticoaguant Therapy in Stroke Patients with Atrial Fibrillation |
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| Affiliation: | LIN ling-ling1 , HUANG Yin-hui2 , LIN You-yu2, CAI Ruo-wei3. ( 1. Department of Neurology, No. 180 Hospital of PLA, Quanzhou 362000, China ; 2. Department of Neurology, the Branch of the Second Affiliated Hospital of Fujian Medical University, Jinjiang 362000, China ;3. Department of Neurology, the Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China) |
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| Abstract: | In the elderly population, stroke is a major cause of death and disability. The most common heart disease related to stroke is atrial fibrillation. About 2/3 strokes in patients with atrial fibrillation are caused by cardiogenic emboli. For stroke patients with atrial fibrillation that without contraindication for thrombolysis, rt-PA thrombolytic therapy is safe and effective, but compared with cases without atrial fibrilla- tion the effect is poorer; for patients with contraindication for thrombolysis, anticoaguant therapy is the most effective secondary prevention measure for the prevention of second-time embolism of stroke patients with atrial fibrillation. Nova anticoagulant dabigatran will become a powerful alternative to warfarin. |
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| Keywords: | Stroke Atrial fibrillation Thrombolysis Anticoagulant |
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