天然免疫相关基因多态性与脓毒症的研究进展

各种遗传变异独立或协同地影响着疾病的发生和发展.脓毒症是感染因素引起的全身炎性反应,可导致器官功能障碍和死亡.基因多态性对脓毒症发病机制的影响作用尚未完全阐明,可能是影响脓毒症发生和预后的重要因素.脓毒症时发生免疫状态紊乱,天然免疫组分损害自身细胞组织,密切影响着脓毒症的转归.近年来有关脓毒症基因多态性的研究主要集中在免疫机制的各个环节.该文就天然免疫中模式识别受体和细胞因子的基因多态性与脓毒症的相关研究进展进行综述.

Genetic Polymorphism Related to Innate Immunity in Sepsis

Diverse genetic variations independently or synergistically influence the process of disease. Sepsis is systemic inflammatory response syndrome induced by inflammatory effectors,which could lead to multiple organ failure and even death. Genetic polymorphisms may play an important rale in pathogenesis and prognosis of sepsis through unknown mechanisms. Immune state disorder appears during sepsis, and innate immune components damages own cel｜ular tissues, affecting the prognosis of sepsis intimately. In recent years, studies of genetic polymorphism in sepsis mainly focus on different aspects in immunologic mecha- nisms. Here is to make a review of the research progress in genetic polymorphism of innate immunity system especially on pattern recognition receptor and cytokines in sepsis patients.