内皮祖细胞与高血压关系的研究进展

血管内皮结构与功能完整使心血管系统处在稳态状态。内皮受损且修复功能受限可导致许多心血管疾病的发生、发展。内皮祖细胞（EPCs）是血管内皮细胞前体细胞,在维持内皮稳态,促进血管内皮修复方面发挥重要作用。近年来对EPCs的研究发现,其与高血压病发生、发展有密切联系,其数量减少和功能紊乱都可能导致人类患高血压病风险增高。而高血压作为独立危险因素对血管内皮祖细胞有损伤作用。该文对EPCs与高血压关系的研究进展进行综述。

Research Progress of Relationship between Endothelia Progenitor Cell and Hypertension

Integrity of vascular endothelial structure and function keeps the cardiovascular system in steady state. Endothelial dysfunction and limited repair ability is thought to result in the development of many vascular diseases. Endothelial progenitor cells are precursors of vascular endothelial cell,which play an important role in maintaining endothelial steady state and promote the vascular repair. In recent years the researchers of endothelial progenitor cells found they are closely related to hypertension disease occurrence and development. The decrease in the number and function disorder could lead to an increased risk for hypertension disease. Hypertension is a damage to endothelial progenitor cells as an independent risk factor. Here is to make a review of the research progress of relationship between endothelia progenitor cell and hypertension.