Expression of Hsp27 and Hsp70 in lymphocytes and plasma in healthy workers and coal miners with lung cancer |
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Authors: | Haijiao Wang Jingcai Xing Feng Wang Wenhui Han Houmao Ren Tangchun Wu Weihong Chen |
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Institution: | 1. Department of Occupational & Environmental Health and MOE Key Lab of Environmental and Health,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China 2. Department of Occupational & Environmental Health and MOE Key Lab of Environmental and Health,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;The Central Hospital of Xishan Coal & Electricity Company,Shanxi 030053,China 3. The Central Hospital of Xishan Coal & Electricity Company,Shanxi 030053,China |
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Abstract: | In coal mines, main occupational hazard is coal-mine dust, which can cause health problem including coal workers’ pneumoconiosis
and lung cancer. Some heat shock proteins (Hsps) have been reported as an acute response to a wide variety of stressful stimuli.
Whether Hsps protect against chronic environmental coal-mine dust over years is unknown. It is also interesting to know that
whether the expression of Hsp27 and Hsp70 proteins as a marker for exposure is associated risk of lung cancer among coal miners.
We investigated the association between levels of Hsp27 and Hsp70 expression in lymphocytes and plasma and levels of coal-mine
dust exposure in workplace or risk of lung cancer in 42 cancer-free non-coal miners, 99 cancer-free coal miners and 51 coal
miners with lung cancer in Taiyuan city in China. The results showed that plasma Hsp27 levels were increased in coal miners
compared to non-coal miners (P<0.01). Except high cumulative coal-mine dust exposure (OR=13.62, 95%CI=6.05–30.69) and amount of smoking higher than 24 pack-year
(OR=2.72, 95% CI=1.37–5.42), the elevated levels of plasma Hsp70 (OR=13.00, 95% CI=5.14–32.91) and plasma Hsp27 (OR=2.97,
95% CI=1.40–6.32) and decreased expression of Hsp70 in lymphocytes (OR=2.36, 95% CI=1.05–5.31) were associated with increased
risk of lung cancer. These findings suggest that plasma Hsp27 may be a potential marker for coal-mine dust exposure. And the
expression of Hsp27 and Hsp70 levels in plasma and lymphocytes may be used as biomarkers for lung cancer induced by occupational
coal-mine dust exposure. |
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Keywords: | Hsp27 Hsp70 lung cancer flow cytometry coal miner |
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