医学生感觉寻求特征与血小板单胺氧化酶活性之间的关系

目的：医学生感觉寻求与MMP1及单胺氧化酶活性关系的探讨，方法：以79名三、四年级医科大学学生为研究对象，进行MMPI，感觉寻求及泽克曼-库赫曼人格问卷测试，同时测定血小板MAO活性，结果：（1）感觉寻求总分，兴奋与冒险寻求得分，经验寻求得分，冲动性感觉寻求得分均与MMPI中的抑郁项得分呈负相关（r=-0.349,P=0.002)(r=-0.23,P=0.l042)(r=-0.431,P=0.000)(r=-0.235,P=0.003)；放纵欲望与MMPI中的轻躁狂项得分呈正相关（r=0.237,P=0.035)。（2）冲动性感觉寻求得分与血小板MAO活性呈显著负相关（r=-0.339,P=0.009)。结论：医学生感觉寻求特征与MMPI抑郁呈负相关，与轻躁狂呈显著正相关。血小板MAO活性可以作为冲动性感觉寻求的生物学标志。

The relationship between sensation seeking and monoamine oxidase activity in medical students

Objective: To study relationship of sensation seeking and MMPI personality and monoamine oxidase activity in medical students. Method: 79 medical students were invastigated with MMPI, Sensation seeking scale (SSS) and Zuckerman-Kuhlman's personality inventory (ZKPQ) ,and platelet MAO activity was measured at the same time. Results: 1. Total sensation seeking score?Thrill and adventure seeking score?Experience seeking score?Impulsive sensation seeking score were negatively correlated to depression score in MMPI (r=-0.349,P=0.002)(r=-0.23,P=0.042)(r=-0.431,P=0.000)(r=-0.235,P=0.003) ; Disinhibition score is positively correlated to hypomania score in MMPI (0.237,P=0.035) ;2. Impulsive sensation seeking score is negatively correlated to platelet monoamine oxidase activity. Conclusions: The trait of sensation seeking is related to depression?hypomania in MMPI; platelet monoamine oxidase activity can be treated as a stable biological marker which is related to the impulsivity-sensation seeking trait.