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卡氏肺孢子虫感染大鼠血清中酶学变化及意义
引用本文:尹卫东,刘克芹,薛贵平. 卡氏肺孢子虫感染大鼠血清中酶学变化及意义[J]. 山东医药, 2007, 47(5): 19-21
作者姓名:尹卫东  刘克芹  薛贵平
作者单位:河北北方学院,河北张家口,075000;河北北方学院附属第一医院
摘    要:目的探讨卡氏肺孢子虫(PC)感染大鼠血清中酶学变化的意义。方法应用地塞米松诱导建立卡氏肺孢子虫肺炎(PCP)大鼠模型(PCP组),于造模前(0周)及造模后3、6、9、12周断尾取血,检测血清中丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)、乳酸脱氢酶(LDH)水平;于12周后采集肺泡灌洗液(BALF)检测ALT、AST、ALP、LDH水平。结果PCP组血清ALP、AST水平从造模第3周以后显著高于正常对照组(P<0.05),ALT及LDH水平无明显规律性变化。结论ALP、AST可作为PCP感染的辅助诊断指标。

关 键 词:肺炎  卡氏肺孢子虫  大鼠  支气管肺泡灌洗液  酶学
文章编号:1002-266X(2007)05-0019-03
修稿时间:2006-11-02

The clinical significance of the changes about enzymes in serum in rats experimentally infected with Pneumocystis carinii
YIN Wei-dong,LIU Ke-qin,XUE Gui-ping. The clinical significance of the changes about enzymes in serum in rats experimentally infected with Pneumocystis carinii[J]. Shandong Medical Journal, 2007, 47(5): 19-21
Authors:YIN Wei-dong  LIU Ke-qin  XUE Gui-ping
Affiliation:1Hebei North University, Zhangjiakou 075000, P. R. China
Abstract:[Objective] To study the clinical significance of the changes about enzymes in serum in rats experimentally infected with Pneumocystis carinii. [Methods] Established animal model with the dexamethasone induction to PCP in rats, the blood of the experimental rats was collected by breaking their tails in 0w before the model; 3, 6, 9 and 12 weeks after the model; to examine the content of ALT, AST, ALP and LDH in serum. The BALF were collected by narcotizing the rats with ethyl ether in 12 week, to examine the content of ALT, AST, ALP and LDH in BALF. [Results] The serum levels of ALP and AST were strikingly higher than those in the control group (P<0.05), the levels of ALT and LDH had no notable regular change. [Conclusion] The levels of ALP,AST can be regarded as a auxiliary diagnosis index for PCP.
Keywords:pneumonia  pneumocystis carinii rat  bronchoalveolar lavage fluid  enzyme
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